Natkho was born the Circassian village of Kfar Kama in northern Israel, to a Circassian-Muslim family. During her childhood Natkho played in a junior Futsal team in the village of Kfar Tavor where she was identified as having great potential. As a result, she was referred to a training camp at the Wingate Institute. Natkho's family, whom acknowledged her great potential, took a decision to support their daughter as much as they can. As a result, when Natkho reached 14 her family moved with her to Even Yehuda so that she would be able to practice and play in the Even Yehuda women's high school basketball team. In her first season in the team, Natkho led the team to its first title in the history of the team - the State Cup. Following her success in the Even Yehuda team in the following year she joined the team of the Ostrovsky High School in Ra'anana, where she studied and played for three years. During her last season in high school, in 2000, her team won the national high school basketball championship. During that season Natkho began playing in the Premier League team Maccabi Raanana. Her breakthrough season came a year later, in which she was selected as the discovery of the season. During her first two seasons in Maccabi Raanana, the team won the State Cup. During her third season in Maccabi Raanana Natkho scored an average of 13.7 points per game, making her Israel's best Shooting guard of that season. In 2003, after four seasons in Maccabi Raanana Natkho was transferred, along with her coach Tal Nathan, to the Elitzur Ramla basketball team. During her first season with the team, the team won the national cup. In 2002 Natkho was invited for the first time to the adult basketball teams, and later on she took part in the European Women Basketball Championship held in Greece during 2003. Two monthsprior to Natkho's death, after many years of living outside of the village of Kfar Kama, the family returned to reside in the village. Natkho only got to play in two games during her second season with the Elitzur Ramla basketball team before she died.
Death
In the evening of November 5, 2004 Natkho was driving her Ford Focus vehicle along with four other people. While driving on Highway 767, in near proximity to her parents' house in the village of Kfar Kama, for an unknown reason her vehicle lost control, swerved into the opposite lane and collided with a Jeep. Both Nili Natkho and her sister Diana were killed instantly, while their cousin Raja Tlash died short after of her injury while being operated in the hospital. The two additional passengers in the car, whom were relatives of Natkho, were severely injured in the accident.
