Nicotine gum


Nicotine gum is a type of chewing gum that delivers nicotine to the body. It is used as an aid in nicotine replacement therapy, a process for smoking cessation and quitting smokeless tobacco. The nicotine is delivered to the bloodstream via absorption by the tissues of the mouth.
It is available over-the-counter in Europe, the US and elsewhere. The pieces are usually available in individual foil packages and come in various flavors. Nicotine content is usually either 2 or 4 mg of nicotine, roughly the nicotine content of one sixth to one third of a cigarette, with the appropriate content and dosage depending on the smoking habits of the user. Popular brands include Nicotex, Nicorette, Nicogum, Nicotinell and Zonnic.
Alternative nicotine replacement products include the nicotine patch, nicotine pastilles/lozenges and the nicotine inhaler.
Nicotine replacement products including gum and transdermal patches are on the World Health Organization's List of Essential Medicines.

Medical uses

Nicotine gum can be used in combination with long acting nicotine replacement therapy formulations such as the nicotine patch. It has been shown that combination therapy is more effective than use of a single agent for tobacco cessation. Nicotine absorption from chewing gum is much lower than during smoking. In addition, extraction of nicotine is incomplete, averaging 53% and 72% for 2 mg and 4 mg gum, respectively, and it varies among individuals.
It is important to recognize that tobacco cessation is treatment of nicotine addiction. As with other types of addiction, pharmacological therapy is not the only component in treating addiction. Behavioral habits must also be treated, and modifications to these behaviors along with pharmacological therapies can greatly impact and improve chances of successful tobacco cessation.

Dosing

Although there are many brands of nicotine gum available, they are dosed in a similar manner. Light smokers, those who smoke less than 15 cigarettes per day, should use the 2 mg gum. Heavy smokers should use the 4 mg. The size of nicotine gum is the same for both strengths.
The dosing regimen provided by the Nicorette gum label is as follows:
WeekPieces of gum
Weeks 1 – 61 piece every 1–2 hours
Weeks 7 – 91 piece every 2–4 hours
Weeks 10 – 121 piece every 4–8 hours

Users should not use more than 24 pieces of gum per day.
Directions for use:
Cautions:
is a vasoconstrictor; it constricts arteries, which increases the resistance against which the heart has to pump blood, effectively making it harder for the heart to pump blood through the body. The result is enhanced shear stress on vessel walls, and repeated nicotine exposure contributes to accelerated health problems that are a function of chronic vascular injury such as coronary artery disease, acute cardiac ischemic events, and hypertension Studies have shown that nicotine exposure contributes to stroke, peptic ulcer disease, and esophageal reflux. Nicotine may also cause wounds to heal more slowly and may be associated with reproductive toxicity.
Nicotine gum requires frequent periods of chewing throughout the day which can lead to jaw soreness. People with dental problems should also be cautious from the effects of constant gum chewing and should consult their dentist before using the nicotine gum.

Muscle control

Two unpleasant symptoms which affect some new users and existing users who make excessive use of nicotine gum, are hiccups and a perceived constriction of the throat muscles, as accidental swallowing of saliva containing high amounts of nicotine may cause irritation.

Special populations

Pregnancy-related complications

Birth defects

Women who use nicotine gum and patches during the early stages of pregnancy face an increased risk of having babies with birth defects according to a 2006 study that looked at about 77,000 pregnant women in Denmark. The study found that women who used nicotine-replacement therapy in the first 12 weeks of pregnancy had a greater risk of having babies with birth defects than women who did not.

Breastfeeding

No studies have been done to show the effects of nicotine gum on breast-feeding. The nicotine from gum will end up in the breast milk. Animal models have shown that nicotine may increase the likelihood of infant death syndrome. It is generally not recommended that breast-feeding mothers use any nicotine products.

Temporomandibular joint disease">Temporomandibular joint dysfunction">Temporomandibular joint disease (TMJ)

Because this medication requires frequent periods of chewing throughout the day, people who have Temporomandibular joint disease should avoid using this medication as it will exacerbate their disease.

Storage and disposal

The nicotine gum should be kept tightly closed in a dry cool place and out of reach of children and pets. Used nicotine gum must be wrapped in paper and put in the trash can. When the medication is no longer needed, do not flush it down the toilet and return it to pharmacies through mail-back service. In case of limited access to mail-back program, see FDA's Safe Disposal of Medicines for further instructions.

Availability

Various policies exist worldwide as to the accessibility of these medications. Originally gum was sold only by prescription.
In most of the EU and the US, nicotine gum is available at pharmacies over-the-counter subject to the same restrictions on underage purchases as tobacco. Depending upon jurisdiction and pharmacy the purchaser may be directed to the pharmacist, or nicotine gum may be purchased off-the-shelf. If sold where tobacco products are also sold, the display of the nicotine therapy products may be adjacent to the tobacco display.
Although nicotine gum can be purchased over the counter, in efforts to promote and support tobacco cessation the FDA has approved the nicotine gum, as well as other NRT agents and two other cessation agents: Varenicline and bupropion, for a tobacco cessation indication. This reduces the cost to many U.S. consumers whose health insurance plans cover or have discounts for prescription but not over-the-counter drugs.
In New Zealand nicotine gum and patches are classified General Sale and can be sold in outlets other than pharmacies, e.g. petrol stations and supermarkets. This has resulted in a steep fall in the retail price, particularly from online New Zealand stores.
This trend away from only being sold over the counter at pharmacies also followed in Australia with sharp price falls in the last year and wide availability. Nicotine gum, lozenges and similar preparations can be now readily found on the shelf in the medicinal aisle of most major chain supermarkets and can be purchased alongside other grocery items.
In the United Kingdom many NRT products are available in shops, supermarkets, petrol stations and even schools, although an age limit of 12 is required. Own-brand NRT products are available from some pharmacy chains. The National Health Service provides NRT at a discounted price or free of charge. Nicotinell was one of the biggest selling branded over-the-counter medications sold in Great Britain in 2016, with sales of £31.2 million.
In Hong Kong the large chain pharmacist shops usually, but not always, require the purchaser of the stronger therapy to sign a register with passport number or Hong Kong ID.
CountryAvailabilityRestrictions
USAOTC18 years of age, even though the US tobacco age is 21, nicotine replacement therapies are not controlled as tobacco products
EuropeOTCSame as purchasing tobacco
New ZealandOTC and General Stores-
AustraliaOTC and General Stores-
Hong KongPharmaciesStrong therapy purchase requires ID