Network of Cancer Genes


Cancer Genes in NCG

The Network of Cancer Genes is a freely accessible web resource of cancer genes and their associated properties. The project started in 2010 and in August 2018 has reached its 6th release: NCG6.0. NCG6.0 reports information on 2,372 protein-coding cancer genes, including 711 known cancer genes from the Cancer Gene Census and the Vogelstein, Science 2013 list. The remaining 1,661 cancer genes are candidate cancer genes annotated from the manual curation of 273 original publications. For each cancer gene NCG6.0 reports its system-level properties, the publications reporting it as a known or candidate cancer gene and information on the design of their cancer sequencing screens. In addition, the database provides annotations on 250 possible false positive genes, defined as candidate cancer genes whose association with cancer is likely to be spurious.

Cancer sequencing screens

The 273 manually annotated publications in NCG6.0 describe a total 278 whole genome or whole exome cancer sequencing screens. These screenings included a total of 34,905 patients from 119 different cancer types. These include cancer sequencing screens of samples from 31 different anatomical sites, as well as 4 adult and 2 paediatric pan-cancer sequencing screens. NCG6.0 allows to perform advanced searches and retrieve information on cancer genes by: primary anatomical site, cancer type, and by sequencing screens or publication.
Primary siteCancer types
BloodDiffuse large B-cell lymphoma, acute lymphocytic leukemia, chronic myeloid leukemia, multiple myeloma, chronic lymphocytic leukemia, cutaneous T cell lymphoma, T-cell leukemia/lymphoma, non-Hodgkin lymphoma, peripheral T-cell lymphoma, Burkitt's lymphoma, angioimmunoblastic T-cell lymphoma, acute myeloid leukemia, cutaneous DLBCL, acute monocytic leukemia, follicular lymphoma, chronic myelomonocytic leukemia, acute lymphoblastic leukemia, myeloproliferative neoplasm, acute promyelocytic leukemia, juvenile myelomonocytic leukemia, myelodysplasia, natural killer/T cell lymphoma, splenic marginal zone lymphoma, mediastinal B-cell lymphoma
BladderBladder cancer
BreastBreast cancer, triple negative breast cancer, breast fibroepithelial tumours, male breast cancer, breast fibroadenoma
BrainDiffuse intrinsic pontine glioma, astrocytoma, paediatric high-grade glioma, glioblastoma, pan-glioma, meningioma, neuroblastoma, low grade glioma, paediatric low grade glioma, glioma, craniopharyngioma, intracranial germ cell, medulloblastoma, oligodendroglioma
PancreasPancreatic cancer, pancreatic ductal adenocarcinoma, pancreatic neuroendocrine tumours, pancreatic neoplastic cysts
Colon and Rectumcolorectal adenocarcinoma
Small IntestineAmpullary adenocarcinoma, duodenal adenocarcinoma, neuroendocrine tumour
HepatobiliaryPan-liver, hepatocellular carcinoma, cholangiocarcinoma, biliary tract cancer, gallbladder carcinoma
StomachGastric adenocarcinoma, diffuse gastric adenocarcinoma, mucinous gastric cancer
LungSmall cell lung cancer, lung cancer, lung adenocarcinoma, lung squamous cell carcinoma, non-small cell lung cancer
Head and NeckSquamous head and neck cancer, nasopharyngeal carcinoma, ameloblastoma, oral squamous cell carcinoma, salivary gland adenocarcinoma
ProstateProstate cancer
Soft tissueAngiosarcoma, soft tissue sarcoma, rhabdomyosarcoma
UterusEndometrial cancer, uterine carcinosarcoma, serous endometrial cancer, leiomyoma, clear cell endometrial cancer
Peripheral Nervous SystemNeuroblastoma, malignant peripheral nerve sheath tumour
ThymusThymic carcinoma
SkinMelanoma, mucosal melanoma, desmoplastic melanoma, skin basal cell carcinoma
KidneyClear cell renal cancer, renal cancer, non-clear cell renal cancer, papillary renal cell carcinoma, rhabdoid tumour, chromophobe renal cell carcinoma, renal angiomyolipoma
Adrenal glandAdrenocortical adenoma, adrenocortical carcinoma, pheochromocytoma, paraganglioma
EsophagusEsophageal squamous carcinoma, esophageal adenocarcinoma, esophageal
BoneOsteosarcoma, Ewing sarcoma, chondrosarcoma, chondromyxoid fibroma, chondroblastoma, bone giant cell tumour
Parathyroid glandParathyroid carcinoma
OvaryOvarian cancer, ovarian serous carcinoma, ovarian clear-cell carcinoma, ovarian small-cell carcinoma
PenisPenile squamous cancer
ThyroidPapillary thyroid cancer, anaplastic thyroid carcinoma
CervixCervical cancer
TestisTesticular germ cell cancer
RetinaRetinoblastoma
PleuraMalignant pleural mesothelioma
UveaMelanoma
Vascular systemVascular cancer

Systems level properties

Systems-level properties are properties of genes independent on an individual's gene function. Some of these properties can be used to distinguish cancer genes from the rest of human genes. The systems-level properties reported by NCG are: