Combee was born in Lakeland and graduated from Polk State College and Florida State University. Following graduation, he worked in agribusiness and real estate. He was elected to the Polk County Commission as a Democrat in 1988, a position to which he was re-elected in 1992, 1996, and 2000. In 2004, Combee did not seek another term on the Commission, and following the conclusion of his term in 2005, he was appointed to the Governing Board of the Southwest Florida Water Management District, where he served until 2012 when he resigned to run for the legislature. Combee was going to run for the legislature in 2010 when incumbent State RepresentativeKelli Stargel was planning on seeking the Florida Senate seat held by Paula Dockery, who planned on running for Governor. When Dockery dropped her gubernatorial campaign, however, Stargel instead ran for re-election, putting her on a collision course with Combee. Ultimately, Combee did not qualify for the ballot because his campaign "wrote a qualifying check for $1,781.81, but the correct amount required was $1,781.82."
When Dockery was term-limited in 2012, Stargel ran to succeed her, creating an open seat in the 39th District, and Combee once again declared his candidacy. He was unopposed in the primary election and faced Carol Castagnero, an independent candidate who had run for a number of offices unsuccessfully, in the general election. Castagnero did not present a strong challenge to Combee, and he ended up defeating her in a landslide, receiving 65% of the vote, to win his first term in the legislature. Combee sponsored legislation in 2013 that would have " someone who fires a warning shot or brandishes a weapon from being prosecuted under the state's stiff gun laws," which he had previously proposed a year prior, but had not received a vote. He attracted controversy in 2013 when he suggested on Twitter that Barack Obama was responsible for the chemical attacks that took place in the Syrian Civil War, asking, "Who knows? Did the White House Help Plan the Syrian Chemical Attack?" He defended his remarks, saying, "I think it's my place, your place and everybody's place to question what is going on here. Who do we believe?"
