NME1
Nucleoside diphosphate kinase A is an enzyme that in humans is encoded by the NME1 gene. It is thought to be a metastasis suppressor.Function
This gene was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase exists as a hexamer composed of 'A' and 'B' isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene generates naturally occurring transcripts, which encodes a fusion protein consisting of sequence sharing identity with each individual gene product.Interactions
NME1 has been shown to interact with:
