Born in Toronto, Ontario, to Romanian-born Jewish immigrant parents, Koffler attended Oakwood Collegiate Institute, and then received a Phm. B. degree in 1946 from the University of Toronto. In 1946, he became a pharmacist at Koffler Drug Stores. From 1968 to 1971, he was President of Koffler Stores Ltd. From 1971 to 1986, he was Chairman of Shoppers Drug Mart. He was appointed an Honorary Chairman in 1986. In addition to his business pursuits, Koffler was a community leader and philanthropist. He received the B'nai B'rith Distinguished Citizen's Award; the Canada Council of Christians and Jews Humanitarian Award; and, with his wife, Dr. Marvelle Koffler, the Israel Cancer Research Fund Humanitarian Award. He served on the board of governors of the Canadian Council of Christians and Jews, as well as those of Mount Sinai Hospital, the United Jewish Welfare Fund, and the Jerusalem Foundation, and is a past chairman of the United Jewish Appeal. In 1979, he was the Toronto Negev Dinner honoree. Murray and Marvelle established the Koffler Centre of the Arts in 1974. The Koffler and Koffler Gallery present a contemporary cross-disciplinary arts program including the Vine Awards for Canadian Jewish Literature and a diverse range of programs in theatre, literature and visual arts. The Marvelle Koffler Breast Centre and the Murray Koffler Urologic Wellness Centre were both established through their generous philanthropy to the Mount Sinai Hospital. In 1969, Koffler rallied the pharmaceutical community, among others, to launch , a charitable non-profit association with the mandate to prevent substance abuse through health promotion and education impacting children and youth. CODA develops/delivers cutting-edge, preventive drug abuse programs to youth aged 12–19 in 104 Canadian school communities which include students/teachers other youth/adults associated with high school and feeder schools, local community groups/social services/community centres/police and other points of community focus including culturally diverse groups/populations. In 1971, Koffler and two other Jewish community leaders, Albert Latner and Ray Wolfe, purchased the Canadian Jewish News. Both Kofflers were major supporters of the Weizmann Institute of Science in Israel. Both sat on the Institute's board of governors, and Murray was chair of the international board of directors. He was also chairman emeritus of the Canadian Society for the Weizmann Institute. Another of his contributions to the Weizmann Institute was his funding of the Koffler Accelerator—a sophisticated twin-tower instrument for nuclear research. In 1979, Koffler opened the first Super-Pharm pharmacy, in Herzliya, Israel. Super-Pharm is still owned by the Koffler family, and there are currently 202 locations in Israel.
Death
Koffler died on November 5, 2017, at his home in Toronto. His widow Marvelle Koffer died on January 14, 2020 at the age of 90.