Large eruptions around 4750 BCE and 1890 BCE are believed to have been of Volcanic explosivity index 6; these are probably responsible for the large caldera. The 4750 BCE eruption may have wiped out many or all of the groups living in central Patagonia at that time, based on evidence from the Los Toldosarchaeological site. Recently, the volcano has had moderate eruptions in 1891 and 1971 as well as a large eruption in 1991.
1971 eruption
Before 1970, little was known about the mountain. Minor eruptive activity began in 1970 and melted parts of the glacier, raising river water levels and leading to the identification of the caldera. In August–September 1971, a moderate eruption located in the northwest area of the caldera sent ash into the air and caused lahars from the melting of a large portion of the glacier. The lahars killed five people; many more were evacuated.
1991 eruption
The eruption in August to October 1991 was a large plinian eruption with a VEI of 5, that ejected 4.3 km3 bulk volume. Parts of the glacier melted and ran down the mountain as mud flows. Due to the remoteness of the area, no-one was killed but hundreds of people were evacuated from the vicinity. Ash fell on Chile and Argentina as well as in the South Atlantic Ocean and on the Falkland Islands. In 1992, John Locke Blake, then resident on Estancia Condor, south of Rio Gallegos, in Argentina describes the effects of the eruption vividly. He describes an ash fall up to 15 cm in depth, covering some 150,000 to 180,000 square kilometres in a triangle from Los Antiguos to Deseado to San Julian to a depth of between 5 and 10 cm. He reports that the hygroscopicity of the silica caused the formation of morasses around drinking places causing sheep to be trapped and die in huge numbers. He records that 'ten years later, most of the farms in the affected area are empty, of sheep and of people'. In addition to the ash, a large amount of sulfur dioxide gas and aerosols were ejected in the eruption. These contributed to those already in the atmosphere from the even larger 1991 eruption of Mount Pinatubo earlier in the year and helped cause a worldwide cooling effect over the following years. Ozone was also depleted, with the Antarctic ozone hole growing to its largest levels ever recorded in 1992 and 1993. As a result of the Mount Pinatubo eruption, the Hudson eruption received little attention at the time.
October–November 2011 eruption
On October 26, the Chilean Service for Geology and Minery issued a red alert and a mass evacuation of the region surrounding the volcano, fearing an imminent eruption in the coming hours or days. It happened on Oct 31 but was small and didn't do any damage to the area.
