Mononegavirales

Use of term

Order inclusion criteria

• its genome is a linear, typically nonsegmented, single-stranded, non-infectious RNA of negative polarity; possesses inverse-complementary 3' and 5' termini; and is not covalently linked to a protein;
• its genome has the characteristic gene order 3'-UTR–core protein genes–envelope protein genes–RNA-dependent RNA polymerase gene–5'-UTR ;
• it produces 5–10 distinct mRNAs from its genome via polar sequential transcription from a single promoter located at the 3' end of the genome; mRNAs are 5' capped and polyadenylated;
• it replicates by synthesizing complete antigenomes;
• it forms infectious helical ribonucleocapsids as the templates for the synthesis of mRNAs, antigenomes, and genomes;
• it encodes an RNA-dependent RNA polymerase that is highly homologous to those of other mononegaviruses; and/or
• it typically produces enveloped virions with a molecular mass of 300–1,000; an S_20W of 550–>1,045; and a buoyant density in CsCl of 1.18–1.22 g/cm³.

  Order organization

Life cycle

Paleovirology