Monoacylglycerol lipase


Monoacylglycerol lipase, also known as MAG lipase, acylglycerol lipase, MAGL, MGL or MGLL is an enzyme that, in humans, is encoded by the MGLL gene. MAGL is a 33-kDa, membrane-associated member of the serine hydrolase superfamily and contains the classical GXSXG consensus sequence common to most serine hydrolases. The catalytic triad has been identified as Ser122, His269, and Asp239.

Function

a chemical reaction that uses water molecules to break the glycerol monoesters of long-chain fatty acids. It functions together with hormone-sensitive lipase to hydrolyze intracellular triglyceride stores in adipocytes and other cells to fatty acids and glycerol. MGLL may also complement lipoprotein lipase in completing hydrolysis of monoglycerides resulting from degradation of lipoprotein triglycerides.
Monoacylglycerol lipase is a key enzyme in the hydrolysis of the endocannabinoid 2-arachidonoylglycerol. It converts monoacylglycerols to the free fatty acid and glycerol. The contribution of MAGL to total brain 2-AG hydrolysis activity has been estimated to be ~85%, and this in vitro estimate has been confirmed in vivo by the selective MAGL inhibitor JZL184. Chronic inactivation of MAGL results in massive elevations of brain 2-AG in mice, along with marked compensatory downregulation of CB1 receptors in selective brain areas.

Inhibitors

MAGL enzyme inhibitors produce cannabinoid behavioral effects in mice.
Further examples include:
  1. KML-29
  2. JZL195
  3. JNJ-42165279
  4. JW 642