During the French and Indian War, the Mohawk Valley was of prime strategic importance; to the British, it provided a corridor to the Great Lakes from which to threaten New France directly, while to the French it provided a corridor to the Hudson Valley and on to the heart of British North America. In addition, many settlements of the Mohawk, Britain's crucial Indian ally at the time of the war, were located in or near the valley. At the beginning of the war, the major British stronghold in the Mohawk corridor was Fort Oswego, located on Lake Ontario. The French captured and destroyed the fort after a short siege in 1756, and the Mohawk Valley lay open to French advance as a result. Although the French did not directly exploit this avenue of attack, its impact swayed some of the Iroquois tribes to the French side.
The original inhabitants of common day Mohawk Valley are traced back as far as 10,000 plus years and included Algonquian people that later relocated from the newly established Fort Orange Dutch trading post region as early as 1624, otherwise as the name implies, the inhabitants were and remained Mohawks. The name Mohawk Valley had its origins in the time period of 1614 and 1624-25 following the settlement of Dutch traders who established a post among the region of the Mohawk of Mohawk Valley as the Mohawk had become alliances and targets of the Indian Wars. The Mohawks of Mohawk Valley call themselves Kanien'keha'ka, and "People of the Flint" in part due to their creation story of a powerful flinted arrow. Among other things, the traditional use of Mohawk Valley flint as Toolmaking Flint is only one attribution to the Mohawk Valley People of the Flint name.
Counties
Schoharie
Montgomery
Fulton
Herkimer
Oneida
Otsego
Also, Schoharie County is sometimes considered to be part of the Mohawk Valley because the Schoharie Creek, primarily located in Schoharie County, is a major tributary that empties into the Mohawk River at Fort Hunter in Montgomery County. Furthermore, the northern border of Schoharie County with Montgomery County is very close to the Mohawk River.
Major cities and villages
;Montgomery County
Amsterdam
Canajoharie
Fonda
Fort Plain
Fultonville
Nelliston
Palatine Bridge
St. Johnsville
;Fulton County
Gloversville
Johnstown
;Herkimer County
Frankfort
Herkimer
Ilion
Little Falls
Mohawk
;Oneida County
Sherrill
Rome
Utica
;Otsego County
Cooperstown
Oneonta
;Schoharie County
Middleburgh
Schoharie
Cobleskill
Popular culture
Drums Along the Mohawk an historical novel written by Walter D. Edmonds, is set in the Mohawk Valley near Deerfield during the American Revolutionary War. It was very carefully researched and portrayed the complexity of the times. The 1939 film of the same name, directed by John Ford, has been criticized for “ the historical complexity of the original for the mythic simplification of an all-American Western.”
Mohawk Valley is an important site in the video game Assassin's Creed III published by Ubisoft. The game takes place during the Revolutionary War era and features an assassin tasked with playing a role in the history of early America.
In season 5, episode 16 "Lecture Circuit" of the American television show, The Office, a sign reading “Mohawk Valley Center” is displayed in the opening seconds of the episode. This sign indicates the Dunder Mifflin UTICA branch. Utica is a city within the Mohawk Valley of New York State.