Moore was a psychiatrist in the Ericksonian tradition. He taught neurology at the Harvard Medical School and the Boston City Hospital. He also conducted research on alcohol and addiction. In a 1937 article published in the New EnglandJournal of Medicine, he argued that alcoholism had become rampant in the United States, and he called for the establishment of special wards for alcoholics in hospitals. Two years later, in the same journal, he argued that the heavier an individual, the less likely they were to feel drunk. By 1943, in the Boston number of the Medical Clinics of North America, he argued that adult neurosis and alcoholism could be prevented if parents ensured children matched the skills of their peers and never "go off the track of normal development". He also published articles in medical journals about "drug addiction, suicide, venereal disease , the psychoneurosis of war, migraine headaches." Meanwhile, Moore also treated patients like Robert Frost's daughter, who suffered from paranoia and depression. During World War II, Moore served as a psychiatrist in the United States Army's Bougainville Campaign as well as in New Zealand. On September 22, 1942, Moore gave a speech about Adolf Hitler's Mein Kampf entitled What Hitler means in "Mein Kampf" at the Fitzsimons Army Medical Center in Aurora, Colorado; a year later, it was reprinted in Military Surgeon. Moore served as Lieutenant-Colonel in Nanking, where he was "director of medical operations". He was the recipient of the Bronze Star Medal for his war service. After the war, Moore played a key behind-the-scenes role in the Ezra Pound controversy, as a member of a group of literary men who saw to it that the modernist icon escaped a treason trial for his radio propaganda in support of Mussolini. Moore was a close friend of one of the psychiatrists on a diagnostic panel that found Pound unfit to stand trial.
Poetry
Throughout his career Moore produced sonnets in a very high volume. Estimates vary but by 1935, Louis Untermeyer had counted 25,000 sonnets in Moore's files, according to a Time Magazine article that year; just over two years later, a 1938 Talk of the Town piece in the New Yorker put Moore's total production of sonnets at 50,000. Moore discovered his affinity for the sonnet form while still in secondary school and is said to have learned shorthand during college in order to be able to write more sonnets between classes. Although some of his work, such as the posthumous quatrain collection The Phoenix and the Bees, is in other forms, the poet-psychiatrist wrote and archived his poems in a dedicated home office he called his "sonnetorium." Some of his books, like Case Record from a Sonnetorium or More Clinical Sonnets, were illustrated by Edward Gorey. It was Moore who put the young Robert Lowell in contact with literary men including Ford Madox Ford, Allen Tate and John Crowe Ransom, and who encouraged Lowell to become a student of Ransom after Lowell's sudden violent break with his family and departure from Harvard.
Moore married to Ann Leslie Nichol in 1930. Together they had four children: Adam, John, Leslie, and Hester. He published articles about conchology. Moore died of cancer on September 21, 1957 in Boston, Massachusetts. He was 54.