His Art Deco-like style established him as a commercial artist, at first via erotic illustrations for sexually oriented magazines such as Blueboy, Viva, and Playboy, the last of which named him their "Illustrator of the Year" in 1980.. In the same year, he provided the cover art for Edmund White's novel Nocturnes for the King of Naples. During the 1980s, his work covered many commercial media. He created album covers for CBS Records and book covers for numerous other novels, usually in the genres of fantasy, mystery, or horror. He provided illustrations for the science/science-fiction magazine OMNI and a front cover for Time magazine. He also received professional recognition from his peers, receiving the Society of Illustrators's Gold Medal in 1982 and a Silver Medal in 1987. He has exhibited his work in New York City at the Cooper-Hewitt Museum and the Society of Illustrators. Edmund White wrote in his Introduction to Dreamer: "Mel Odom's work represents an original synthesis of...two moments in the history of taste: a recuperation of art-nouveau perversities of the past but in a shiny, shadowless, innocently hedonistic space....In Mel Odom's world the perverse has become at last a candid pleasure...a vision of utopia." In 1990, Odom proposed to design the cosmetic facepaint for Mdvanii, a 25 cm limited-edition collector's fashion doll. The experience renewed his childhood interest in dolls and led him to create a doll of his own, the 15.5" Gene Marshall. Gene Marshall's appearance, wardrobes, and history are modelled on the glamour of Hollywood's golden age from the 1920s through 1950s. The doll made its commercial debut at the 1995 Toy Fair and was an immediate success, creating a wider market for large, fully articulated collector's fashion dolls in contrast to the slightly smaller and less flexible Barbie doll. Since then, Odom has largely concentrated his professional pursuits on the Gene Marshall doll, regularly modifying her design to create new variations and creating similar companion dolls to share her world, such as Gene's "co-stars" Madra Lord, Violet Waters, and Trent Osborn. Odom continues to attend doll collectors' conventions to make personal appearances and buy dolls for his own collection, as well as to support charitable causes. At a 1997 doll convention entirely devoted to Gene Marshall, a charity auction of uniquely modified Gene dolls raised more than $30,000 for Gay Men's Health Crisis, an AIDS service organization.
