Anderson played her first game of netball at the age of 8 at the St John the Baptist netball club, Woy Woy, due to her mother's participation as an umpire. Much of Anderson's junior playing was competing in the Woy Woy Peninsula Netball Association, at the Lemon Grove Park netball courts, Lagoon Street, Ettalong Beach. Anderson was the first player to feature in both the National Bank Cup and Commonwealth Bank Trophy competitions at the same time.
Anderson played for the Adelaide Ravens and the Sydney Swifts in the Commonwealth Bank Trophy. She also had a two-year stint in New Zealand with the Northern Force in the National Bank Cup. With the start of the new trans-Tasman ANZ Championship, Anderson was signed with New Zealand team the Southern Steel for the 2008 season. The Steel tried to sign her again for the 2009 season, but she was ruled ineligible by Netball New Zealand. Anderson subsequently signed with the Queensland Firebirds, but later pulled out of the team before the start of the season citing work commitments. In June 2009, Anderson gained special dispensation to rejoin the Steel as a replacement for the then pregnant shooter Daneka Wipiiti. Anderson announced a return to the ANZ Championship in 2010 for the Southern Steel after great performances starring with the World 7 team who recently toured New Zealand. For the 2011 ANZ Championship season Anderson signed with the Northern Mystics after attempts to gain NZ residency were unsuccessful to allow her to be a part of the Southern Steel for another year. Anderson's move came about due to the Steel signing Natasha Chokljat from the Melbourne Vixens which meant that under the Championship rules the Steel would have had two ineligible players on their books. On 14 July 2000, she was awarded the Australian Sports Medal for netballing achievements. Anderson retired as a player from the ANZ Championship and the Northern Mystics at the conclusion of the 2011 season and was retained by the Mystics as a specialist coach. Anderson is currently the Assistant coach for the NSW Swifts in the ANZ Championship. In 2015 due to her coaching achievements Megan was awarded the Elite Coaching Accreditation at the Court Craft Night Interdistrict.