Meclofenamic acid


Meclofenamic acid is a drug used for joint, muscular pain, arthritis and dysmenorrhea.
It is a member of the anthranilic acid derivatives class of NSAID drugs and was approved by the FDA in 1980. Like other members of the class, it is a COX inhibitor and prevents formation of prostaglandins.
Scientists led by Claude Winder from Parke-Davis invented meclofenamate sodium in 1964, along with fellow members of the class, mefenamic acid in 1961 and flufenamic acid in 1963.
Patents on the drug expired in 1985 and several generics were introduced in the US, but as of July 2015 only Mylan still sold it.
It is not widely used in humans as it has a high rate rate of gastrointestinal side effects. As of 2015 the cost for a typical course of medication in the United States is 50 to US$100.

Use in horses

Meclofenamic acid is sold under the trade name "Arquel" for use in horses, and is administered as an oral granule form at a dose of 2.2 mg/kg/day. It has a relatively slow onset of action, taking 36–48 hours for full effect, and is most useful for treatment of chronic musculoskeletal disease. It has been found to be beneficial for the treatment of navicular syndrome, laminitis, and osteoarthritis, in some cases having a more profound effect than the commonly used NSAID phenylbutazone. However, due to cost, it is not routinely used in practice. Toxicity due to excessive dosage is similar to that of phenylbutazone, including depression, anorexia, weight loss, edema, diarrhea, oral ulceration, and decreased hematocrit.