Mira was born in Stoneham, Massachusetts on August 5, 1983 and grew up in Lowell, Massachusetts. He is the youngest of four children. His parents are John and Mary Mira. He has two older sisters Kimberly and Julie, and an older brother John. He was raised Catholic, and attended Lowell Catholic High School. After high school he attended local colleges. He left Massachusetts for Los Angeles in 2007 to pursue a career in comedy. From 2008 to 2010, while working as an Apple Genius, Mira produced the podcast Comedy and Everything Else featuring Todd Glass and Jimmy Dore. Since February 2010, Mira has co-hosted The Nerdist Podcast, with Jonah Ray and Chris Hardwick. The podcast was named one of 2010's best by The A.V. Club. Mira has appeared as a guest on several other podcasts, including Sklarbro Country and Doug Loves Movies. In 2011 Mira produced ONESTAR, a show at UCB Theatre Los Angeles with comedian Thomas Lennon in which comedians and actors performed "dramatic readings of the YELP reviews of the Koreatown24 Hour Fitness." Mira now hosts a weekly open mic at the NerdMelt theatre at Meltdown Comics in Los Angeles titled Nerdist Open Mic, formerly titled Matt Mira's Day Off. In May 2011, BBC America commissioned a pilot based on The Nerdist Podcast, hosted by its creator, comedian Chris Hardwick and featuring Jonah Ray and Mira in their usual co-hosting roles. Mira announced on The Nerdist Podcast that he had accepted a job as the new gadget producer on G4's Attack of the Show. In January 2012, he began making on-air appearances for the segment. Beginning in July 2012, Mira co-hosted Attack of the Show up until its final episode on January 23, 2013. A video featuring a golf-cart running over Matt has been featured on the TV showstosh.0, Country Fried Home Videos, and World's Dumbest.... Beginning in March 2012, Matt began co-hosting an occasional podcast with film producer Scott Mosier called FEaB, a joint production of Nerdist Industries and SModcast.com. As of September 2013, Matt co-hosts James Bonding with Matt Gourley, an Earwolf podcast where they discuss James Bond movies. Since October 2013, Mira has been writing for the Chris Hardwick hosted @midnight on Comedy Central. On June 19, 2015, Kevin Smith announced via Facebook that he and Mira "will provide a commentary track for every single episode of Frasier" on a new podcast entitled Talk Salad & Scrambled Eggs- Frasier Reconsidered w/ Matt Mira & Kevin Smith. As of 2016, Mira currently is writing for The Goldbergs on ABC. He also hosts a podcast with his wife Doree Shafrir about their journey about making a baby with science called Matt & Doree's Eggcelent Adventure. Starting January 8, 2017, Matt began co-hosting the podcast 'Star Trek: The Next Conversation' with fellow 'The Goldbergs' writer Andrew Secunda. On September 22, 2017, Matt was named host of After Trek, a live after-show companion to broadcast on CBS All Access.