Memon launched her political career as an advisor within Pakistan's Board of Investment, her primary role being advising the Minister of Strategies on marketing Pakistan's profitable sectors. She joined Pakistan Muslim League in 2007 and was elected to the National Assembly of Pakistan in 2008 general election on a reserved seat for women from Punjab. During her tenure as MNA, she served as a member on the opposition benches, and held various positions including a member of the standing committee of Environment, Information Technology and Kashmir. Her work paid particular focus on rural and urban vulnerabilities faced by women. Some of her key legislative pieces include:
The Acid and Burns Crime Legislation, which also became the subject of Pakistan's first Oscar winning documentary
Legislation to set up the Pakistani Institute of Parliamentary Services, which is Pakistan's first research and training institute for parliamentarians
Procedures and obligations of airlines after air crashes
Supreme Court of Pakistan's Flood Commission Report which is a technical report taking account of climate change, and government obligations pre and post flooding
Rights of rural women faced with honour killings
Worker rights in the agriculture sector
Memon resigned from the National Assembly in 2011 and left the PML-Q in protest after the party joined the PPP led-coalition government. In 2012, she launched her memoir, My Parliamentary Diaries, an account of everyday life as a parliamentarian. Memon joined Pakistan Muslim League in 2012, and was elected to the National Assembly on a reserved seat for women from Sindh. Memon initially served as Prime minister's youth wing coordinator before she was appointed Chairperson of the Standing Committee for Information Broadcasting and Heritage. During her tenure as Chairperson, the Committee passed through various reforms with the objective of maintaining legislative oversight over the Federal Government's information Ministry. In February 2015, she was appointed Chairperson of Benazir Income Support Programme with status of Minister of State. In April 2017, she was appointed as the member of the Advisory Council on Gender and Development at World Bank. She ceased to hold the status of Minister of State when the federal cabinet was disbanded after Nawaz Sharif resigned as Prime Minister. Following the election of Shahid Khaqan Abbasi as the new prime minister in August 2017, she was re-appointed as the Minister of State in the federal cabinet of Prime Minister Shahid Khaqan Abbasi and was elevated to federal minister in the federal cabinet of Prime Minister Shahid Khaqan Abbasi until the dissolution of the National Assembly on the expiration of its term in May 2018. In November 2018, Memon founded the Lifelong Learners Consultancy, providing consultancy services on development, national security, women empowerment, medium management and poverty alleviation to organisation, universities, governments and corporates.