In January 2010, following a cabinet reshuffle, President Mills replaced Cletus Avoka with Amidu as the Minister for Interior. As Amidu is a Builsa, some people raised questions as to his neutrality in dealing with the Bawku conflict. He however went successfully through vetting by the Parliament of Ghana and assumed his post.
Attorney general
Following the second major cabinet reshuffle by President Mills, Amidu became the Attorney general and Minister for Justice of Ghana.
Removal from Office
Martin Amidu was relieved of his post on Thursday January 19, 2012 by President John Evans Atta Mills under circumstances described by aids as 'his misconduct' at a meeting chaired by the president at the Osu Castle on January 18, 2012. He made allegations related to alleged financial impropriety on the part of another cabinet minister, allegations he was asked by the president to substantiate. Martin Amidu, the former Attorney General, single-handedly challenged the legality of the payments after being relieved off his post at the Supreme Court. The Supreme Court in 2014 ordered Mr. Woyome to pay back the money as Supreme Court judges unanimously granted the Attorney-General clearance to execute the court’s judgment, ordering Mr. Woyome to refund the cash to the state. Following the delays in retrieving the money, Mr. Amidu in 2016, filed an application at the Supreme Court seeking to examine Alfred Woyome, on how he would pay back the money, after the Attorney General’s office under the Mahama Administration, led by the former Minister for Justice, Marietta Brew Appiah-Oppong, discontinued a similar application. In February 2017 however, Mr. Amidu withdrew his suit seeking an oral examination, explaining that the change of government under the New Patriotic Party under His Excellency the President, Nana Addo Dankwah Akuffo Addo and his Attorney General, Miss Gloria Akuffo’s assurance to retrieve all judgment debts wrongfully paid to individuals Mr. Woyome in response prayed the Supreme Court to stay proceedings on the oral examination since he had filed for a review on the case. His lawyer, Ken Anku, argued that, his client will face an irreparable damage if the oral examination is allowed to take place but the deputy Attorney General, Godfred Dame, opposed the application, describing the reasons as incompetent and unmeritorious according to citifmonline.
He is Ghana's first Special prosecutor nominated for parliament's approval. The nomination was announced by the President of Ghana Nana Akufo-Addo on January 11, 2018. Martin A.B.K. Amidu was sworn into office on Friday, February 23, 2018 by President Nana Addo Dankwa Akufo-Addo at the Flagstaff House. Amidu at the swearing in ceremony thanked the Attorney General and the President for appointing him, and promised to fight corruption in the country without fear or favour.