As a college freshman, in 1971, Ginsberg began serving as a legislative assistant to Senator Edward Kennedy when he was Chairman of the Senate Subcommittee on Refugees until 1977. In 1977, the United States Secretary of State appointed Ginsberg to serve as White House Liaison. Under President Jimmy Carter, from 1979 until 1981, he was Deputy Senior Advisor to the President for Middle East Policy. In 1994, President Bill Clinton appointed Ginsberg the Ambassador to Morocco, making Ginsberg the first Jewish American to be appointed as an ambassador to a country in the Arab World. Ginsberg was the first United States diplomat to Morocco to be awarded the Highest Order of Ouissam—a knighthood—by Hassan II, the king of Morocco at that time. Between 1998 and 1999, he served as the United States Special Coordinator for Mediterranean Trade, Investment, and Security Affairs. Ginsberg has also worked as a reviewer of United States foreign and economic policy for groups such as the Council on Foreign Relations and the Brookings Institution. From 2000 to 2012, Ginsberg served as senior vice president and managing director of APCO Worldwide—a global corporate public affairs and communication consultancy. Ginsberg coordinated strategic client relationships and business planning throughout the Middle East. Ginsberg was co-founder and served as president of Layalina Productions. Layalina is a non-profit producer of commercial Arabic-language television, the first United States organization to produce such content for broadcasting in the Arabic world. Layalina has its headquarters in Washington, D.C. and in Amman, Jordan. Ginsberg served a two-year term on the board of directors of the AARP Foundation from 2009 to 2011. In 2013, Ginsberg became Chief Executive Officer of the and Chief Executive Officer of Peaceworks LLC and resigned in November 2014. Ginsberg remains a senior adviser. With offices in Israel, Palestine, the United Kingdom, and the United States, the One Voice Movement fosters grassroots advocacy among the next generation of Israelis and Palestinians to promote a two-state solution to the Arab–Israeli conflict. Ginsberg regularly contributes articles to periodicals such as The Washington Post, the Wall Street Journal, the Financial Times, the International New York Times, the Baltimore Sun, and the Huffington Post. Ginsberg serves on the Middle East Advisory Board of the Rand Corporation and on the boards of other Middle East organizations.