It played an imported role as Orthodox spiritual center during the 17th and 18th centuries. In 1628 at the Kyiv church synod Manyava Skete was granted the status of "prot", the principal heading monastery over the monasteries in the Ruthenian, Belz and Podolian Voivodeships. Over 500 monasteries in Ukraine, Moldova and Romania were under its control. The Orthodox monastery of Manyava was founded and developed in period between 1606 - 1785. The founding father of the monastery is Saint Job of Maniava, who was monk on the Greek Athos for some time before. In 1606, together with Ivan Vyshensky and religious writer Zakhariya Kopystensky of Kyiv Pechersk lavra he organized the first monk community here. In 1618 there were 40 monks residing in the skete. In 1621 the monastery was granted stauropegic status and that meant its direct subordination to the Patriarch of Constantinople. Right after its renovation in 1781, it was unexpectedly closed down by Austrian authorities on 1 July 1785. The monastery in Maniava was reestablished with the collapse of communism in Ukraine in the early 1990s, nearly 200 years later. The clairvoyant hegumen Ioann / John, known for his kind-heartedness, was the first head of Manyava Skete after it was reopened. Many Orthodox faithful from Ukraine, Russia and Poland sought his help. Having foreseen his death, he died in 2003 and is buried on the territory of the monastery and his grave is much venerated by the Orthodox pilgrims. Already after his death, he appeared in a dream to one of the monks waking him up with words "Stand up, you are burning" when the electrical wiring was on fire in the monastery. This happened to be true and saved the Skete from the fire.
Marian apparitions
In 1652 there was the plagueepidemic in skete and the neighbouring areas. Many monks were dying from it. The remaining monks were pleading to God for mercy. On December 22, 1652 the Manyava hieromonk Filaret had a dream vision of Blessed Theotokos being dressed in a red hegumen´s cloak, who came in through the monastery gates and entered the Church of Annunciation of Virgin Mary and having stopped there, said. "The plague will already stop". In remembrance of this event there is an icon "Hegumenia of the Manyava monastery" kept in the skete.
Manyava Skete is also famous for its "Blessed Stone", regarded as a place of prayer and of the spiritual purification. The stone reminds a giant cave with the space of 10 x 3 meters, a typical dwelling of the solitary monks, a skete. This was a first place, where the founding monks settled in the 13th century. The spring of healing water emits from underneath the Blessed Stone. It is being said that the water has the same healing properties as the waters of Lourdes. The spring ceased when the monastery was closed and miraculously started flowing again with the reopening of Maniava Skete.