Wilson was born in New York City into a Roman Catholic family of Irish and Scottish extraction. He had three siblings. His father, Charles H. Wilson, was a patent attorney who unsuccessfully ran for a seat in the State Assembly in 1912. His mother, Agnes, was a Republican activist and local party leader. The family moved to Yonkers, New York, when Wilson was eight, and Wilson continued to reside there after he began his career.
At age 24, just two years after graduating from Fordham Law, Wilson was elected to the New York State Assembly where he represented the 5th district of Westchester County from 1939 to 1945, and after re-districting the 1st district from 1945 to 1959. He sat in the 162nd, 163rd, 164th, 165th, 166th, 167th, 168th, 169th, 170th and 171st New York State Legislatures. During his tenure as a legislator, Wilson sponsored a large number of bills that became law. Among his bills that came into law was the Wilson Pakula Act, which prevented candidates from running in a party primary if they were not members of that party. His political and legal careers were interrupted by the outbreak of World War II. Wilson joined the United States Navy in 1943 and served on an ammunition ship, traveling to Europe several times. He was discharged in 1945 as a Lieutenant, Junior Grade. While he was at war, Wilson won reelection to the Assembly in absentia.
Rockefeller's right-hand man
In 1958, Wilson decided to support Rockefeller for Governor despite the fact that the latter was a political novice and had never run for office before. Wilson took pains to introduce Rockefeller to many politically powerful people in the state. They would frequently travel in Wilson's personal car in order to play down the candidate's wealth. Rockefeller was nominated for governor, and Wilson for lieutenant governor. The Rockefeller-Wilson ticket defeated the incumbent Democrats W. Averell Harriman and George DeLuca. Wilson's served as lieutenant governor for nearly 15 years, the entirety of Rockefeller's governorship. The Rockefeller-Wilson ticket was reelected in 1962, 1966 and 1970. Throughout his tenure, he tended to agree with Rockefeller's liberal Republicanism, with the notable exception of abortion, the legalization of which Wilson opposed. Wilson defined himself as "an economic conservative and a human-rights liberal".
In December 1973, Rockefeller resigned as governor to run the Commission on Critical Choices for Americans, and Wilson assumed the governorship. he completed the remaining year of Rockefeller's term and ran for election to a full term in 1974. The period was a difficult one for the nation, both in terms of economic and foreign policy and for the Republican Party, which was weakened by the Watergate scandal. Democrats swept to power across the nation in the 1974 general election, with Wilson losing the governor's mansion to Hugh Carey, who won with 58% of the vote. While governor, Wilson worked to improve passenger rail service the state and under his leadership, New York City-Albany-Montréal and New York City-Buffalo-Detroit service were revived. Concerned that city governments, especially New York City, were financing their budgets with financial sleight-of-hand, Wilson warned New York State's mayors that there would be a reckoning unless they got their fiscal houses in order. His warning turned out to be prescient when New York City was found to be nearly bankrupt, and had to resort to federal assistance to regain a sound footing. But Wilson's concern over government finances turned into a campaign issue for Carey in the 1974 election, when an agency under Wilson's purview, the state's Urban Development Corporation, was discovered to be near bankruptcy. After taking office, Carey accused Wilson of hiding the severity of the crisis, and complained that the Wilson administration had not been helpful or engaged during the transition between governors.
Wilson had two daughters, Katharine, an attorney, and Anne, and six grandsons. Wilson was a Catholic and attended the St. Denis Catholic Church in Yonkers, New York.