Domi was born in Elbasan. He started his high school studies in the Norman School there, and finished them in the French Lyceum of Korçë in 1937. After that he registered in the University of Grenoble in France, from where he graduated in classic philology in 1941. The same year he started teaching at the Normal School of Elbasan, and later he became its director. From 1947, he started working in the Institute of Sciences, and lecturer at the High Pedagogical Institute in Tirana. Domi participated as co-editor in the Albanian language dictionary in 1954. With the establishment of the University of Tirana, he was put in charge of the Albanian language catedra, and also of the grammar and dialectologysection of the Institute of Language and Literature during 1957–1991. He taught the courses "Syntax of the Albanian language", "Historical morphology of the Albanian language", and "History of Albanology". He was one of the founding members of the Academy of Sciences and member of its presidium. Domi's scientific activity covers many of fields of philology: grammar, language history, history of Albanology, dialectology and onomastics, normative linguistics, language culture, scientific critics, history of literature, etc. He directed the work for establishing the cartotheque of grammar and the important work Gramatika e gjuhës shqipe, in two volumes; he was its chief editor, and co-author and editor of its second volume. He drafted out the academic textbooks Morfologjia historike e shqipes of 1961, Sintaksa e gjuhës shqipe, part I in 1968 and part II in 1969. He also contributed with a series of scientific articles and researches over general topics of the Albanian syntax and its structural development. In the field of the history of literature, Domi wrote articles and researches over the origins of the Albanian language, its connection to other Balkan languages, especially with Romanian, i.e. Prapashtesa ilire dhe shqipe, përkime dhe paralelizma of 1974, Konsiderata mbi tiparet e përbashkëta të shqipes me gjuhët ballkanike dhe mbi studimin e tyre of 1975, Mbi disa përkime dhe paralelizma sintaksore shqipe-rumune of 1977, Probleme të historisë së formimit të gjuhës shqipe, arritje dhe detyra of 1982. As one of the main personalities in linguistics, Domi was member of the commissions who carries the task of standardizing the Albanian orthography, in 1956 and 1967, co-organizer and participant of the Orthography Congress of November 1972, member of the follow-up commission for deploying the new orthographic rules and co-author of the Drejtshkrimi i gjuhës shqipe of 1973, Fjalori drejtshkrimor of 1976, Rregullat e pikësimit në gjuhën shqipe of 1981. Domi participated in many commissions which would draft out dictionaries of terminologies from various fields, between others Fjalori i termave të gjuhësisë of 1975. He was the organizer and main co-contributor to the work that resulted in the publishing of the Atlasi dialektologjik i gjuhës shqipe, Dialektologjia shqiptare, both works of major importance. He was also initiator of the collection of the onomastic material, co-author of the questionnaire for the collection of toponymy, and articles on them. Domi also studied also the old Albanian literature written in Arabic alphabet, and contributed to the literature section in the major work Historia e letërsisë shqipe, vol. I of 1959, published by the University of Tirana, and served as editor for the second volume of 1983 published by the Academy of Sciences of Albania. As a recensé, Domi contributed in the evolvement of the scientific critics culture in Albania.
