MSin3 interaction domain
The mSin3 interaction domain is an interaction domain which is present on several transcriptional repressor proteins including TGFβ and Mad. It interacts with the paired amphipathic alpha-helix 2 domain of mSin3, a transcriptional repressor domain that is attached to transcription repressor proteins such as the mSin3A corepressor.
Action of histone deacetylase 1 and 2 is induced by the interaction of mSin3A with a multi-protein complex containing HDAC1/2. Transcription is also repressed by histone deacetylase-independent means.
