MERTK


Proto-oncogene tyrosine-protein kinase MER is an enzyme that in humans is encoded by the MERTK gene.

Function

This gene is a member of the TYRO3/AXL/MER receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa.