Lymphoid enhancer-binding factor 1
Lymphoid enhancer-binding factor 1 is a protein that in humans is encoded by the LEF1 gene.Function
Lymphoid enhancer-binding factor-1 is a 48-kD nuclear protein that is expressed in pre-B and T cells. It binds to a functionally important site in the T-cell receptor-alpha enhancer and confers maximal enhancer activity. LEF1 belongs to a family of regulatory proteins that share homology with high mobility group protein-1.Clinical significance
LEF1 is highly overexpressed and associated with disease progression and poor prognosis in B-cell chronic lymphocytic leukemia and other kinds of malignancies like colorectal cancer. It is also a promising potential drug target.Interactions
Lymphoid enhancer-binding factor 1 has been shown to interact with:
