Luke was a native of the Greek village of Kastorion. He was the third of the seven children of Stephen and Euphrosyne. The Life, typically for the genre, begins with signs of Luke's closeness to God as a child. For instance, Luke is recorded as having done 'nothing in a childish fashion', and is seen to be close to God when his mother witnesses him levitating in prayer. The son of poor farmers, the saint worked in the fields and tended sheep. As a child Luke tried twice to leave home to seek a solitary life of prayer. The first time, he attempted to withdraw to Thessaly, but was captured by soldiers lying in wait for escaped slaves and was returned home. The second time he had more success, meeting two monks journeying from Rome to Jerusalem who took him to a monastery in Athens where he received the small habit. After Luke's mother prayed for her son's return however, God made her appear in a dream to the abbot and commanded him to return Luke to his home.
Asceticism
At the age of 14, with his mother’s blessing, he went to a solitary place on a mountain called Ioannou and for 7 years lived as an ascetic. The Life records with symmetry that during this time Luke received the great habit from two monks travelling from Jerusalem to Rome. Luke's fame spread and a number of miracles are ascribed to him during this period, such as revealing to two brothers the location of their dead father's buried treasure. Numerous proofs of Luke's holiness are also given, such as sleeping in a trench to remind himself of death, or being visited in dream by an angel who let a hook down Luke's mouth and 'drew out a certain fleshly member therefrom', freeing him from the temptations of the flesh.
Exodus
Luke was forced to leave Ioannitza by an invasion of the Bulgarian emperorSymeon. Luke, followed by the local villagers, fled to a nearby island, almost perishing when attacked by Bulgarians in a stolen ship. After the invaders withdrew, Luke, now aged 21, enrolled in a school in Corinth, but soon left after he found the other students insufficiently serious. Instead, he went to serve a stylite at Zemena for the next ten years, until he was stranded in the Peloponnese on an errand when the harbour master refused to allow him to return to Hellas, fearing raids. When Luke was ejected from his oratory in the Peloponnese after a rainstorm, his hagiographer comments that 'God perhaps arranged these things beneficially, lest dwelling too long in the land of Pelops he do an injustice to his fatherland', perhaps indicating a rival cult of the saint in the Peloponnese and providing an interesting example of patriotism towards the theme.
Return
The Life also cites Symeon's death in 927 and the succession of his more pacific son Peter as a reason why Luke returned to Ioannitza to build his own community. Luke drew so many followers that he found the distractions unbearable and decided to retreat further into the wilderness. Three years later, however, Luke was displaced again, this time by a Magyar invasion. Just as before, Luke retreated with the local villagers to a nearby island. Once there, Luke found the desert island to be a suitable place to pursue his solitary ascetic life, and stayed for three years, enduring terrible thirsts. Eventually Luke's companions persuaded him to leave, and he settled for the remainder of his life in the far more amenable environment of the present Hosios Loukas, where he founded his hermitage c. 946 AD in the area of Stiris. Here brethren gathered to the elder, and a small monastery grew up, the church of which was dedicated to the Great Martyr Barbara. Dwelling in the monastery, the saint performed many miracles, healing sicknesses of soul and of body.