Vettonianus had an inauspicious start to his career, as a tresviri capitales, one of the magistracies that comprised the vigintiviri. This was the least desirable office of the four, for men who held that office rarely had a successful career: Anthony Birley could find only five tresviri capitales who went on to be governors of consular imperial provinces. Following this he was commissioned a military tribune with Legio VI Victrix, then stationed at the city of Legio in Hispania Tarraconensis. After serving as a quaestor in Sicily, he accepted another commission as a military tribune with Legio IV Scythica in AD 62, stationed at Zeugma in Syria. At one point Vettonianus found himself commanding the legion under the leadership of Lucius Caesennius Paetus in the Roman–Parthian War of 58–63. The legion, however, was defeated in the Battle of Rhandeia and suffered dishonor. The next posts Vettonianus held were civilian ones: prefect of the aerarium Saturni, curator of the Via Aemilia, and curator aequarum. These were obviously all held after Nero's death, proving he was rehabilitated by Vespasian of the dishonor from Rhandeia. The prefecture of the aerarium Saturni could be precisely dated to c. 74-c. 76, but the date of the rest pose a problem. While the prefecture could be held by an ex-praetor, and thus before Vettonianus was suffect consul, the curatorship of the roads was more often held after the consulate, and that of the water supply always was; but the inscription grouped them together, as if Vettonianus held them before acceding to the consulate. It may be that as similar positions, it made sense to group them together in the inscription, or Vettonianus was adjunct curator aequarum to the man usually considered his predecessor, Manius Acilius Aviola. After his nundinium as suffect consul, Vettonianus was appointed governor of Dalmatia in 79, and held the post through 84, the first of several imperial provinces he held without interruption. Next was governor of Pannonia in 85/86, then from a point before 5 September85 he governed Moesia Superior until 88. While governor of Moesia Superior, Vettonianus participated in the Dacian Wars with such valor he was awarded the dona militaria appropriate for an ex-consul. Vettonianus capped his career with the proconsulate of Africa in 91-92. He was also appointed to a priesthood in the sodales Augustales, but was later promoted to the septemviri epulonum before his death. Vettonianus' tomb was erected on the Via Latina. His possible descendants include Titus Pomponius Antistianus Funisulanus Vettonianus, suffect consul in the year 121, and Funisulana Vettulla, the wife of Gaius Tettius Africanus Cassianus Priscus, prefect of Egypt.
