Louis Siminovitch Louis "Lou" Siminovitch , is a Canadian molecular biologist . He was a pioneer in human genetics , researcher into the genetic basis of muscular dystrophy and cystic fibrosis , and helped establish Ontario programs exploring genetic roots of cancer. Born in Montreal , Quebec to parents who had emigrated from Eastern Europe, he won a scholarship in chemistry to McGill University , earning a doctorate in 1944. He then studied at the Pasteur Institute in Paris. In 1953 he joined Toronto's Connaught Medical Research Laboratories . Later he joined the University of Toronto and worked there from 1956 to 1985. One of his doctoral students was Joyce Taylor-Papadimitriou . He helped establish the Department of Genetics at the Hospital for Sick Children as geneticist in chief, where he worked from 1970 to 1985. From 1983 to 1994 he was the founding director of research at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital . He is the founder and the first Chair of the Department of Molecular Genetics at the University of Toronto , then called Department of Medical Cell Biology. He is the author or coauthor, at last count, of over 147 scientific papers , reviews, and articles in journals and books. He married Elinore, a playwright who died in 1995. They had three daughters. The annual Elinore & Lou Siminovitch Prize in Theatre is named in his and his wife's honour.Degrees 1941 B.Sc. McGill University, Montreal, Quebec 1944 Ph.D. McGill University, Montreal, Quebec 1978 D.Sc. Memorial University , St. John's, Newfoundland 1978 D.Sc. McMaster University , Hamilton, OntarioHonours In 1941 he won the Anne Molson Prize in Chemistry In 1965 - Fellow, Royal Society of Canada In 1967 - Canadian Centennial Medal In 1977 - Queen Elizabeth II Silver Jubilee Medal In 1978 he won the Royal Society of Canada Flavelle Medal In 1980 he was made an Officer of the Order of Canada . In 1980 - Fellow, Royal Society In 1981 he received the Gairdner Foundation Wightman Award . In 1981 he received the Izaac Walton Killam Memorial Prize . In 1988 he was promoted to Companion of the Order of Canada . In 1997 he was inducted into the Canadian Medical Hall of Fame . In 1999 he was named a foreign associate, and the only Canadian, to the National Academy of Sciences . In 2012, he was made a member of the Order of Ontario . He was awarded a Doctor of Science , Honoris Causa from several Canadian Universities including Memorial University, McMaster University, Université de Montréal , McGill University, University of Western Ontario , University of Toronto and University of Guelph .Selected publications Siminovitch, L., McCulloch, E.A., Till, J.E. The distribution of colony-forming cells among spleen colonies. Journal of Cellular and Comparative Physiology 62 :327-36. Till, J.E., McCulloch, E.A., Siminovitch, L. A stochastic model of stem cell proliferation , based on the growth of spleen colony-forming cells. Proceedings of the National Academy of Sciences 51 :29-36. McCulloch, E.A., Siminovitch, L., Till, J.E. Spleen-colony formation in anemic mice of genotype WWv. Science 144 :844-846. McCulloch, E.A., Siminovitch, L., Till, J.E., Russell, E.S., Bernstein, S.E. The cellular basis of the genetically determined hemopoietic defect in anemic mice of genotype Sl/Sld. Blood 26 :399-410. Wu, A.M., Till, J.E., Siminovitch, L., McCulloch, E.A. Cytological evidence for a relationship between normal hematopoietic colony-forming cells and cells of the lymphoid system. J Exp Med 127 :455-464.
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