Louis Cazeneuve, in his native Argentina and under his given name Luis Cazeneuve, drew one of his country's first adventurecomic strips, Quique, el Niño Pirata, which appeared both daily and Sunday in the newspaperEl Mundo, beginning in 1931 or 1934. Cazeneuve also drew the adventure strips Aventuras de Caza del Pibe Palito and Aventuras de Dos Argentinos en un País Salvaje before emigrating to the United States in 1939. He worked briefly at Eisner & Iger, one of the primary comic-book "packagers" that supplied outsourced comics on demand for publishers at the dawn of the new medium. Shortly thereafter, Cazeneuve, with his artist brother Arthur and Eisner & Iger colleague Pierce Rice, formed a studio that produced freelance art for a number of comics companies. Cazeneuve's earliest work includes Fox Feature Syndicate's 1940 comic stripBlue Beetle, succeeding Jack Kirby under the house nameCharles Nicholas. With writer Joe Simon, editor-in-chief of Marvel Comics predecessor Timely Comics, he co-created the character Red Raven — the first Timely/Marvel character to star in his own self-titled series, predating by several months Captain America Comics #1. From 1940 to 1942, Cazeneuve contributed to a number of Fox titles, drawing the stories introducing the superheroic characters Samson ; the Eagle ; the Banshee ; and U.S. Jones, as well as the villainous protagonist Nagana, Queen of Evil. Other Fox features for which he either supplied full art or did inking over penciler Pierce Rice, include "Captain Savage, Sea Rover", "Chen Chang", "D-13", "The Flame", "The Green Mask", and "Marga the Panther Woman". Also during this time he did occasional work for Centaur Publications, Fawcett Comics, Holyoke Publications, Lev Gleason Publications, and Harvey Comics,. One source attributes the Fox character Spider Queen to the Cazeneuve brothers under the jointpseudonymElsa Lesau.
It was at National Comics, the future DC Comics, that Cazeneuve did his most popular and prolific work during the Golden Age of Comics. He began on minor features, including "Bart Regan, Spy", in Detective Comics #61-63, 65-66, ; "Three Aces", in Action Comics #47-63 ; "TNT and Dyna-Mite", in Star Spangled Comics #10-23 ; and "Radio Squad", in More Fun Comics #81-82. Cazeneuve then began the two features for which he became best known. He succeeded creator Creig Flessel on the modern-day Arthurian feature "Shining Knight", drawing the feature for nearly three years in Adventure Comics #73-101. More prominently, he became the second artist of the enduring character Aquaman, succeeding artist co-creator Paul Norris to become the longest-running artist of the undersea hero's Golden Age adventures. Cazeneuve debuted on "Aquaman" in More Fun Comics #82, and continued with the feature through issue #107, and its subsequent move to Adventure Comics #103-117, 119-120, 124. He additionally drew the wartime "kid gang" feature "Boy Commandos" in World's Finest Comics #14-20, and penciled it in #24. He inked two of their stories by co-creator and writer-penciler Jack Kirby in #21, and inked Curt Swan in #31. Other DC characters on which Cazeneuve worked during the Golden Age include the Crimson Avenger, Green Arrow, the Seven Soldiers of Victory, and the Old West gunslinger Vigilante. One generally authoritative source states that Cazeneuve was ghost-artist for Jack Kirby on some stories in Boy Commandos #6-7. Cazeneuve's other mid- to late Golden Age work included Feature Comics' "Yank and Doodle", and Harvey Comics' "Boy Heroes", "Captain Freedom", and "Shock Gibson". His last known credited DC Comics work is penciling and inking the six-page Aquaman story "The Sea Serpent" in Adventure Comics #124. He then worked primarily for Fawcett Comics, starting with Whiz Comics #103. Cazeneuve's last known credited comics work is penciling and inking the seven-page Western feature "Golden Arrow" in Whiz Comics #107.