Lost Creek (St. Francis River tributary)
Lost Creek is a stream in Wayne County in the U.S. state of Missouri. It is a tributary of the St. Francis River.
The stream headwaters occur at the confluence of the West Fork Lost Creek and East Fork Lost Creek at currently within Lake Wappapello and the confluence with the St. Francis River is at also within Lake Wapapello.
Lost Creek was so named either due to its status as a losing stream or due to a pioneer incident in which a man became lost near its course.