The community's history dates back to the mid-19th century when a bolsonaquifer named "Van Horn Wells" was discovered in the area. These wells were the only known water sources within a radius of. The springs became a stop on the San Antonio-El Paso Road, followed by emigrants travelling to the West. Later followed by the San Antonio-San Diego Mail Line and Butterfield Overland Mail and other mail routes from 1857 until the railroads arrived. In 1882, the area became a watering stop and depot for the Southern Pacific Railroad. A post office was established in 1907 under the name Lobo, after the Mexican wolves that formerly roamed the area. Two years later, a town site was laid out. With the creation of Culberson County in 1911, Lobo vied unsuccessfully with nearby Van Horn to become the new county's seat of government. By 1915, the community had a population of approximately twenty with a general store and several other businesses. A 1929 earthquake destroyed Lobo's hotel. Another powerful earthquake struck the community in 1931. By the mid-1930s, the number of inhabitants had fallen to ten. The post office closed in 1942, but the arrival of the Texas Mica Company and two railroad houses caused a slight increase in the population. Large scale irrigation commenced in the late 1940s and in the following years, cotton became an important crop in the local economy. Anderson, Clayton and Company set up a gin in Lobo, but in 1962, the railroad stop shut down. The population approached ninety by the mid-1960s. Around that time, the water table dropped dramatically and the wells were unable to supply enough water for residents and businesses. The cost of keeping the irrigation pumps operational skyrocketed, and the cotton gin shut down. In 1969, Bill Christ bought the entire community and opened a new gas station as well as a general store. Although business was initially good, the sale of alcoholic beverages caused an increase in crime. The store was destroyed by fire in 1976. In 1988, Christ placed the community on the market for $60,000. By 1991, with no purchaser and faced with personal problems, Christ abandoned his effort to save Lobo. It became a modern ghost town with limited water and an annual rainfall of around per year. On November 5, 2001, three residents from Frankfurt, Germany purchased Lobo. Their plans included fixing up dilapidated buildings and holding local arts and music festivals. The Desert Dust Cinema festival was held in Lobo in 2011, 2012,, 2016, and September 2018. There are no future dates planned.
