Arlington was the youngest of six children born to English emigrants Henry and Mary Stride. She grew up in Mahanoy City, Pennsylvania, where she played baseball with her father and brothers. On June 20, 1891, at age 13, Arlington took the field as the pitcher for the Mahanoy City baseball team against the visitingCincinnati Reds. Reds' manager Mark Lally, impressed with her play, immediately recruited and signed her to play for his team. Arlington played three seasons with the Reds, including two where she shared pitching duties with Maud Nelson. Arlington played for the Young Ladies Baseball Club of New York in 1894 and the other Young Ladies Baseball Club of New York in 1895.
In 1898, sporting and theatrical promoter William J. Connor engaged Arlington for $100.00 a week and negotiated with Atlantic League president Edward G. Barrow for her to sign a minor league contract. She debuted later that year while pitching for the reserve team of the Philadelphia Nationals, and continued to pitch and play infield against several professional clubs in exhibition games around the country throughout the summer. On July 5, 1898, Arlington became the first woman to play for a professional men's baseball team when she pitched the ninth inning for the Reading Coal Heavers against the Allentown Peanuts. Reading was leading 5-0 heading into the final inning when Arlington entered the game. Though she allowed two hits and walked a batter to load the bases, Arlington succeeded in retiring the next three batters to preserve the victory, as the crowd enthusiastically shouted "Good for Lizzie!" The Reading Eagle newspaper reported that more than a thousand fans, including 200 women, attended the game to see what Arlington looked like and what she wore. She entered the grounds in a "stylish carriage drawn by two white horses" and, responding to applause by lifting her cap, revealed her hair done in the latest fashion. She wore black stockings and a gray uniform with knee-length skirt. During the pre-game practice, Arlington played second base like a professional, "even down to expectorating on her hands and wiping them on her uniform", according to the report. The verdict of the Eagle's sports writer was that Arlington might do all right among amateurs but lacked control and the strength to get much speed in the ball. However, he added, "for a woman, she is a success." A writer for the Hartford Courant, anticipating her coming to play for the locals against the Newark team, commented, "It is said that she plays ball like a man and talks ball like a man and if it was not for her bloomers she would be taken for a man on the diamond, having none of the peculiarities of women ball players." But authorities cancelled the appearance of Arlington in Hartford, reportedly because the home team management wanted to take no chances on losing the game, and thereafter her name disappeared from the sports pages.
