List of people from Massachusetts
This is a list of people who were born in/raised in, lived in, or have significant relations with the American state of Massachusetts. It includes both notable people born in the Commonwealth, and other notable people who are from the Commonwealth. People from Massachusetts are called "Massachusettsans" or "Bay Staters" after the Commonwealth's nickname.
Architects
- Lucius W. Briggs – architect
- Charles Bulfinch – architect
- Elias Carter – architect
- Theophilus P. Chandler Jr. – architect
- Josephine Wright Chapman – architect
- Stephen C. Earle – architect
- William LeBaron Jenney – architect
- Samuel McIntire – architect
- Josep Lluís Sert – Spanish architect; Dean of Harvard Graduate School of Design
Artists
- Harvey Ball – inventor of the smiley face
- Will Barnet – painter
- Frank Weston Benson – painter
- Dawn Clements – artist
- George Condo – artist and sculptor
- John Singleton Copley – painter
- Thomas Dewing – painter
- Charles Dana Gibson – graphic artist
- Duff Goldman – cake artist
- Nancy Graves – sculptor, painter, engraver and film director
- Childe Hassam – painter
- Winslow Homer – painter
- Peter Laird – co-creator of the comic book Teenage Mutant Ninja Turtles
- Fitzhugh Lane – painter
- Jack Levine – painter
- Shawn McManus – comic book artist
- Willard Metcalf – painter
- Tony Millionaire – cartoonist, illustrator
- Lilla Cabot Perry – impressionist
- Ted Rall – political cartoonist
- Robert Reid – painter
- René Ricard – poet, art critic, painter
- Norman Rockwell – artist
- Paul Ryan – cartoonist
- Albert Pinkham Ryder – painter
- Mark Shasha – painter, author
- Stass Shpanin – visual artist listed in Guinness Book of World Records as world's youngest professional artist
- Edward Simmons – painter
- Frank Stella – artist
- Andrew Stevovich – artist
- Edmund Charles Tarbell – painter
- Abbott Handerson Thayer – painter
- James Abbott McNeill Whistler – artist
- N. C. Wyeth – artist
- John Wolcott Adams – illustrator
Sculptors
- Russell Gerry Crook – sculptor
- Cyrus Edwin Dallin – sculptor; Olympic archer; namesake of Cyrus E. Dallin Art Museum
- Murray Dewart – sculptor
- Daniel Chester French – neoclassical sculptor
- Joseph Skinger – metalsmith and sculptor
Athletes
- Kim Adler − bowler
- Harry Agganis − baseball player
- Nick Ahmed − baseball player
- Kiko Alonso − football player
- Tony Amonte − hockey player
- Prince Amukamara − football player
- Jim Arvanitis − martial artist, MMA trainer
- Paul Azinger − golfer, television commentator
- Jerry Azumah − football player
- Jeff Bagwell − baseball player
- Sasha Banks − professional wrestler, ring name of Mercedes Kaestner-Varnado
- Tom Barrasso − hockey player
- Dana Barros − basketball player
- Mark Bavaro − football player
- Tyler Beede − baseball player
- Joe Bellino − football player, Heisman Trophy winner
- Mackenzy Bernadeau − football player
- Travis Best − basketball player
- David Blatt − basketball player and coach
- Brian Boyle − hockey player
- Ron Brace − football player
- John Brebbia − baseball player
- Andy Brickley − hockey player
- Charles Brickley − football player and coach
- Aimee Buchanan − American-born Olympic figure skater for Israel
- Nick Buoniconti − Hall of Fame football player
- Chris Capuano − baseball pitcher
- Mary Carew − sprinter, Olympic gold medalist
- Michael Carter-Williams − basketball player
- Brett Cecil − baseball player
- John Cena − professional wrestler
- Jacques Cesaire − football player
- Gosder Cherilus − football player
- Jack Chesbro − Hall of Fame baseball player
- Alex Cobb − baseball player
- Mickey Cochrane − Hall of Fame baseball player
- Chris Colabello − baseball player
- Tim Collins − baseball player
- Todd Collins − football player
- Marc Colombo − football player
- Tony Conigliaro − baseball player
- Stephen Cooper − football player
- Charlie Coyle − hockey player
- Jim Craig − USA Olympic hockey player, 1980 Lake Placid
- Honey Craven − equestrian
- Candy Cummings − Hall of Fame baseball player
- Tim Daggett − gymnast
- Ron Darling − baseball pitcher, television commentator
- Vinny Del Negro − basketball player, head coach
- Tony DeMarco − welterweight champion boxer
- Zak DeOssie − football player for New York Giants
- Eli Dershwitz − Under-20 World Saber Champion, and US Olympic saber fencer
- Mike DeVito − football player for Kansas City Chiefs
- Oliver Drake − baseball pitcher
- Rich Dubee − baseball coach
- Leo Durocher − Hall of Fame baseball manager
- Adam Edelman − American-born four-time Israeli National Champion in skeleton event, and Israeli Olympian
- Mike Eruzione − USA Olympic hockey player, 1980 Lake Placid
- Patrick Ewing − Hall of Fame basketball player
- Mark Fidrych − baseball pitcher, 1976 AL Rookie of the Year
- Ray Fitzgerald − baseball player
- Kenny Florian − UFC Fighter
- Doug Flutie − NFL quarterback, CFL Hall of Famer, Heisman Trophy winner
- Nate Freiman − baseball player
- Chris Gamble − football player
- Breno Giacomini − football player
- Peter Giunta − football coach
- Tom Glavine − baseball pitcher
- Gracie Gold − Olympic figure skater
- Jared Goldberg − Olympic skier
- Colin Grafton − figure skater
- Frank Grant − Hall of Fame baseball player
- Mike Grier − ice hockey player
- Josh Grispi − WEC fighter
- Matt Grzelcyk − hockey player
- Bill Guerin − hockey player
- Marvin Hagler − champion boxer
- Pete Hamilton − NASCAR driver
- Matt Hasselbeck − football player
- Tim Hasselbeck − football player
- Steve Hathaway − baseball pitcher
- Steven Hauschka − football player
- Ed Healey − NFL Hall of Fame player for Chicago Bears
- Chris Herren − basketball player
- Rich Hill − baseball pitcher
- James Ihedigbo − football player
- Jarrett Jack − basketball player
- Tim Keefe − 19th-century baseball pitcher
- Nancy Kerrigan − Olympic figure skater
- Kofi Kingston − WWE wrestler
- Joe Lauzon − UFC fighter
- Peter Laviolette − hockey player, head coach
- Erika Lawler − U.S Olympic women's hockey team
- Michael Leach − tennis player
- Dana LeVangie − baseball player, coach
- Howie Long − Hall of Fame football player, sportscaster
- Connie Mack − Hall of Fame baseball manager
- Rabbit Maranville − Hall of Fame baseball player
- Rocky Marciano − undefeated heavyweight boxer
- Obi Melifonwu − football player for the Oakland Raiders
- David Merkow − golfer
- Lou Merloni − baseball player
- Alex Meyer − Olympic open water swimmer
- Mike Milbury − hockey player and coach
- Wayne Millner − Hall of Fame football player and coach
- Sean Newcomb − basketball player
- Nerlens Noel − basketball player
- Ryan O'Rourke − baseball player
- Rob Oppenheim − professional golfer
- Kassim Osgood − football player
- Francis Ouimet − golfer
- Jay Pandolfo − hockey player
- Craig Patrick − hockey player
- Carlos Peña − baseball player
- Joe Philbin − football coach
- Brian Piccolo − football player
- Tom Poti − hockey player
- John Quinlan − professional wrestler
- Aly Raisman − Olympic gymnast
- Jeff Reardon − baseball player
- Jerry Remy − baseball player, broadcaster
- Patrick Ricard − football player
- Jorge Rivera − UFC fighter
- Richard Rodgers − football player
- Jeremy Roenick − hockey player
- Annette Rogers − sprinter, Olympic gold medalist
- Dan Ross − football player
- Joe Sacco − hockey player
- Alicia Sacramone − Olympic gymnast
- Sandy Saddler − champion boxer
- Zach Sanford − hockey player
- Cory Schneider − hockey player
- Anthony Sherman − NFL player
- Simon Shnapir − Olympic medalist pairs skater
- Jarrod Shoemaker − triathlete
- Jared Shuster − baseball pitcher
- Craig Smith − basketball player
- Jack Sharkey − world heavyweight boxing champion
- John L. Sullivan − first world heavyweight boxing champion
- Lofa Tatupu − football player
- Keith Tkachuk − hockey player
- Jordan Todman − football player
- Bill Toomey − gold medal decathlete, 1968 Olympics
- Pie Traynor − Hall of Fame baseball player
- Mark van Eeghen − football player
- Jimmy Vesey − hockey player
- Noah Vonleh − basketball player
- Pete Walker − baseball pitcher, coach
- Micky Ward − boxer
- David Warsofsky − National Hockey League player
- Turk Wendell − baseball pitcher
- Sara Whalen − American Olympic soccer player
- Jerry White − baseball player
- Ryan Whitney − hockey player, Spittin' Chiclets podcast host
- Jamila Wideman − female basketball player, lawyer and activist
- Jermaine Wiggins − football player
- Brian Wilson − baseball pitcher
- Mark Wohlers − baseball pitcher
- Wilbur Wood − baseball pitcher
- Willy Workman − American-Israeli basketball player for Israeli team Maccabi Haifa
- Blidi Wreh-Wilson − football player
- Antoine Wright − basketball player
- Paul Wylie − Olympic figure skater
Business
- Sheldon Adelson − chief executive officer of Las Vegas Sands Corp.
- Benjamin Bates IV − entrepreneur, namesake of Bates College
- Michael Bloomberg − founder of Bloomberg L.P. and 108th Mayor of New York City
- Amar Bose − inventor
- Horace Bowker − farm economist and businessman
- Edward Goodwin Burnham − industrialist, Connecticut state senator
- Safra A. Catz − president of Oracle Corporation
- John S. Chen − chief executive officer of BlackBerry Ltd.
- Al Davis − former owner of the Oakland Raiders
- Elias Hasket Derby − reportedly America's first millionaire
- James Dole "Pineapple King" − founder of Dole Food Company
- Dan Duquette − General Manager of the Baltimore Orioles
- Thomas C. Durant − vice-president of the Union Pacific Railroad
- William C. Durant − founder of General Motors and Chevrolet
- John Wesley Emerson − founder of the Emerson Electric Company
- Theo Epstein − General Manager of the Chicago Cubs; previously with Boston Red Sox
- Aaron Feuerstein − inventor
- Dave Gettleman − General Manager of the Carolina Panthers
- Crawford Greenewalt − president of DuPont
- Reed Hastings − chief executive officer of Netflix
- Irwin M. Jacobs − co-founder and former chairman of Qualcomm
- Howard Deering Johnson − founder of the Howard Johnson's chain
- Leo Kahn − co-founder of Staples Inc.
- Joseph P. Kennedy Sr. − businessman, investor, U.S. ambassador to United Kingdom
- Robert Kraft − owner of the New England Patriots
- Jeffrey Lurie − owner of the Philadelphia Eagles
- Eunice Kennedy Shriver – founder of the Special Olympics; sister of President John F. Kennedy
- George Swinnerton Parker − founder of Parker Brothers games
- David Portnoy – founder of Barstool Sports
- Sumner Redstone − entertainment mogul
- Henry Huttleston Rogers − industrialist
- James Harris Simons − mathematician, billionaire hedge fund manager
- Jes Staley − chief executive officer of Barclays
- Jack Welch − chief executive officer of General Electric
- Oliver Winchester − founder of the Winchester Repeating Arms Company
- Robert Wolf − Chairman and CEO of UBS's Group Americas division
Civil rights leaders and political activists
- Susan B. Anthony − social reformist, suffragist
- David Bossie − political activist, president of Citizens United
- Frederick Douglass − abolitionist, social reformist; lived in New Bedford and Lynn
- W. E. B. Du Bois − civil rights activist, co-founder of the NAACP
- Abby Kelley Foster − suffragist and abolitionist
- Elizabeth Fox-Genovese − feminist historian and writer
- Elizabeth Freeman − slave in Sheffield; sued for and won freedom on basis of state constitution, 1781
- Margaret Fuller − journalist and suffragist
- William Lloyd Garrison − abolitionist, journalist, and social reformist
- Prince Hall − abolitionist and leader in the free black community in Boston
- Abbie Hoffman − political activist, co-founder of the "Yippies"
- Horace Mann − U.S. Congressman, educationist, and abolitionist
- Grover Norquist − president of advocacy group Americans for Tax Reform
- Nathaniel Raymond − human rights investigator and anti-torture advocate
- Lucy Stone − suffragist and abolitionist
- Neera Tanden − president of Center for American Progress
- Quock Walker − slave in Worcester County; won freedom on basis of state constitution, 1781
- Malcolm X − civil rights activist; lived in Roxbury in the early 1940s
Crime
- Elizabeth Borden − murderer, acquitted
- James J. "Whitey" Bulger − mobster, leader of Winter Hill Gang
- Albert DeSalvo "Boston Strangler" − criminal
- Thomas DeSimone − gangster
- "Anthony the Animal" Fiato − mobster
- Stephen "The Rifleman" Flemmi − gangster
- Jimmy Flynn − mobster, actor
- Mark Foley − U.S. Congressman, criminal
- David Gilbert − radical activist
- George "Boston George" Jung − drug trafficker, smuggler
- Bernard "Bernie" McLaughlin − gangster
- Edward "Punchy" McLaughlin − gangster
- James "Buddy" McLean − mobster
- James "Spike" O'Toole − mobster
- Jacob D. Robida − neo-Nazi, criminal
- "Handsome Johnny" Roselli − mobster for the Chicago Outfit
- Frank Salemme − mobster, hitman
- Frank Wallace − gangster
- Howie Winter − mobster
- Nathaniel Bar-Jonah − convicted child molester, suspected serial killer and cannibal
- Nicola Sacco and Bartolomeo Vanzetti – Italian immigrants who were defendants in a controversial murder trial for an armed robbery of a shoe company in Braintree, Massachusetts
Entertainment
Comedians
- Edwin Adams – comedian, stage actor
- Orny Adams – comedian, actor, Teen Wolf
- Fred Allen – radio comedian
- Anthony Barbieri – comedy writer and performer, Jimmy Kimmel Live!
- Mike Birbiglia – comedian
- Andrew Bowen – comedian, MADtv
- Bo Burnham – comedian
- Bill Burr – comedian, actor
- Louis C.K. – comedian, actor, director, Louie
- Bryan Callen – comedian, actor
- Mario Cantone – comedian
- Steve Carell – comedian, actor, The Office
- Robert Carlock – producer, writer, 30 Rock
- Jessica Chaffin – comedian and actor, The Heat
- Lenny Clarke – comedian and actor, Rescue Me
- Jerry Colonna – comedian, singer
- Dane Cook – comedian and actor; Retaliation, Harmful If Swallowed
- Nate Corddry – comedian, actor, The Daily Show
- Rob Corddry – comedian, actor, The Daily Show with Jon Stewart
- Rob Delaney – comedian, writer
- Jamie Denbo – comedian, actress, Terriers
- Nick DiPaolo – comedian
- Rachel Dratch – comedian, Saturday Night Live
- John Ennis – comedian, actor, Mr. Show with Bob and David
- Spike Feresten – comedy writer, television personality
- Christian Finnegan – comedian, actor, Are We There Yet?
- Gary Gulman – comedian
- Pete Holmes – comedian, comedy writer, television personality, voice-over actor
- Penn Jillette – comedian, illusionist, juggler, writer
- Mindy Kaling – comedian, actress The Office US, The Mindy Project
- Robert Kelly – comedian, actor, NYC 22
- Jen Kirkman – comedian, actress, writer, SuperNews!
- John Krasinski – comedian, actor The Office US
- Denis Leary – comedian and actor
- Jay Leno – comedian and talk show host
- Jason Mantzoukas – comedian and writer, The League
- Matt Mira – comedian, writer, and podcaster
- Eugene Mirman – comedian and writer, Bob's Burgers
- BJ Novak – comedian, actor, head writer of The Office US
- Conan O'Brien – comedian and talk show host
- Patrice O'Neal – comedian, writer
- John Pinette – comedian, actor
- Amy Poehler – comedian, actress, Parks and Recreation
- Paula Poundstone – comedian
- Joe Rogan – comedian, actor
- Faith Salie – comedian, actress, radio host, Significant Others
- Lew Schneider – comedian, actor, writer, Everybody Loves Raymond
- Matt Selman – writer, producer, The Simpsons
- Tom Shillue – comedian, host of Red Eye
- Jenny Slate – comedian, actress, Saturday Night Live
- Doug Stanhope – comedian
- Steve Sweeney – comedian and actor
- Jimmy Tingle – comedian and actor
- Nancy Walls – comedian, actress
- Steven Wright – comedian, actor
Television and film
- Ben Affleck – Oscar-winning screenwriter, director and actor; Good Will Hunting, Argo
- Casey Affleck – actor, Oscar-winning actor, Manchester by the Sea
- Jack Albertson – Oscar-winning actor
- Jane Alexander – Emmy and Tony Award-winning actress
- Kristian Alfonso – actress
- Christopher Allport – actor
- Shawn Andrews – actor
- John Ashton – actor
- Elizabeth Banks – actress
- Susan Batson – actress, producer
- Michael Beach – actor
- Tobin Bell – actor
- Paul Benedict – actor
- H. Jon Benjamin – voice actor; Bob's Burgers, Archer
- Traci Bingham – actress, model
- Vail Bloom – actress
- Verna Bloom – actress
- Eric Bogosian – actor, playwright; , Talk Radio
- Ray Bolger – actor
- Walter Brennan – Academy Award-winning actor
- Paget Brewster – actress
- Clarence Brown – director
- Phil Brown – actor
- Wally Brown – actor
- Jere Burns – actor
- Steve Carell – actor, The Office, The 40-Year-Old Virgin
- Richard Carle – actor
- Corey Carrier – actor
- Max Casella – actor
- Peggy Cass – actress, television personality
- John Cazale – actor
- John Cena – actor and WWE Champion
- Kevin Chapman – actor
- Michael Chiklis – actor
- Etan Cohen – screenwriter
- Misha Collins – actor
- Jennifer Coolidge – actress
- Nate Corddry – actor, The Daily Show with Jon Stewart, Studio 60
- Rob Corddry – The Daily Show with Jon Stewart,
- Marcia Cross – Desperate Housewives
- Monique Gabriela Curnen – actress
- Jane Curtin – actress
- Matt Damon – Academy Award-winning screenwriter and actor; Good Will Hunting, The Bourne Identity, The Departed
- Bette Davis – actress
- Geena Davis – Academy Award-winning actress; Thelma and Louise
- Billy De Wolfe – actor, comedian, singer, voice actor Frosty the Snowman
- Ken Doane – wrestler
- Ed Donovan – Monster, Acts of Mercy
- Jeffrey Donovan – actor; Burn Notice
- Illeana Douglas – actress
- Rachel Dratch – actress, Saturday Night Live
- Anne Dudek – actress
- Olympia Dukakis – Academy Award-winning actress
- Eliza Dushku – actress
- Richard Dysart – actor
- Lisa Edelstein – actress
- Ben Edlund – producer, writer
- Charles H. Eglee – Emmy Award-winning producer and writer
- Lee Eisenberg – producer, writer
- John Enos III – actor
- Kathryn Erbe – actress
- Chris Evans – actor
- Charles Farrell – actor
- Guy Ferland – film and television director
- Betty Field – actress
- Alison Folland – actress
- Ben Foster – actor
- Arlene Francis – actress
- Samuel Fuller – director, screenwriter
- Sabina Gadecki – model, actress
- Christos Gage – screenwriter
- Pamela Gidley – actress
- Paul Michael Glaser – actor, director
- Nick Gomez – director
- Ruth Gordon – actress
- Joey Graceffa – YouTube personality, actor
- Sprague Grayden – actress
- Ari Graynor – actress
- Adam Green – actor, director, screenwriter
- Lynnie Greene – actress, writer, producer
- Clark Gregg – actor, screenwriter
- Scott Grimes, actor
- Paul Guilfoyle – actor
- Jack Haley – actor
- Anthony Michael Hall – actor
- Pooch Hall – actor
- Neil Hamilton – actor
- Jane Hamsher – film producer
- Ziad Hamzeh – director, writer, producer
- Van Hansis – actor
- G Hannelius – actress
- Jay Harrington – actor
- Jesse Heiman – actor
- John Michael Higgins – actor
- Nichole Hiltz – actress
- Marin Hinkle – actress
- Judith Hoag – actress
- John Hodgman – The Daily Show, "I'm a PC" in Get a Mac
- Hal Holbrook – actor
- Marie Jansen – musical actress
- Ann Jillian – actress
- Amy Jo Johnson – actress
- Chris J. Johnson – actor
- JoJo – actress, singer
- Jennifer Jostyn – actress
- Madeline Kahn – actress, singer
- Mindy Kaling – actress, Inside Out, The Mindy Project
- Ben Karlin – comedian, The Daily Show with Jon Stewart, The Colbert Report
- Joe Keery – actor, Stranger Things
- David E. Kelley – Emmy Award-winning writer and producer
- Jean Louisa Kelly – actress
- Arthur Kennedy – actor
- The Klimaszewski Twins – models, actresses
- John Krasinski – actor, The Office
- Ben Kurland – The Artist
- Denis Leary – actor, Rescue Me, A Bug's Life, Ice Age
- Matt LeBlanc – actor, Friends
- Rex Lee – actor
- Jack Lemmon – Academy Award-winning actor
- Jay Leno – comedian and host, The Tonight Show
- Joseph E. Levine – producer
- Richard Libertini – actor
- Laura Linney – actress
- Alexander Mackendrick – director
- Rob Mariano – Survivor contestant
- Nora Marlowe – actor
- Erica McDermott – actress
- Neal McDonough – actor
- Richard McGonagle – actor
- Melinda McGraw – actress
- Ed McMahon – television personality, The Tonight Show Starring Johnny Carson, Star Search
- Terrence E. McNally – actor
- Julie McNiven – actress
- Maria Menounos – Entertainment Tonight, Extra
- Jan Miner – actress
- Eugene Mirman – voice actor
- William Monahan – screenwriter
- Agnes Moorehead – Emmy Award-winning actress
- David Morse – actor
- Robert Morse – actor, singer
- Ebon Moss-Bachrach – actor
- Bridget Moynahan – actress
- Peter Murnik – actor
- Donna Murphy – actress
- Alexandra Neil – actress
- Barry Newman – actor
- Julianne Nicholson – actress
- Leonard Nimoy – actor, Star Trek, IMAX voiceover
- Alessandro Nivola – actor
- Lance Norris – actor, The Judge
- Edward Norton – actor, American History X, The Incredible Hulk
- B.J. Novak – actor, The Office
- Conan O'Brien – television personality, Late Night with Conan O'Brien
- Tricia O'Kelley – actress
- Gretchen Palmer – actress
- Benjamin John Parrillo – actor
- Estelle Parsons – Academy Award-winning actress
- Adrian Pasdar – actor
- Elizabeth Perkins – actress
- John Bennett Perry – actor
- Matthew Perry – actor
- Rebecca Pidgeon – actress
- Joseph Pilato – actor
- Maryann Plunkett – actress
- Amy Poehler – actress, Saturday Night Live, Inside Out
- Ellen Pompeo – Old School, Grey's Anatomy
- Robert Preston – actor
- Alan Rachins – actor
- Natalie Ramsey – actress
- Kim Raver – actress
- Joseph D. Reitman – actor
- James Remar – actor
- Patrick Renna – actor
- Robert Richardson – Academy Award-winning cinematographer
- Alex Rocco – actor
- Eli Roth – director, screenwriter, actor; Hostel
- Harold Russell – Academy Award-winning actor
- Kurt Russell – actor, Escape from New York
- Damien Sandow – born Aaron Haddad, professional wrestler
- Taylor Schilling – actress
- Fred J. Scollay – actor
- Tom Everett Scott – actor
- John Slattery – actor
- Hillary B. Smith – actress
- Paul L. Smith – actor
- Talisa Soto – actress
- James Spader – Emmy Award-winning actor; The Blacklist, Boston Legal
- Caroll Spinney – puppeteer of Big Bird and Oscar the Grouch on Sesame Street
- Andrew Stanton – director, screenwriter, producer
- David Starzyk – actor
- Skipp Sudduth – actor
- Erik Per Sullivan – actor
- Liam Kyle Sullivan – the "Kelly" Skits
- Julie Taymor – director
- Casey Patrick Tebo – director
- Robin Thomas – actor
- Uma Thurman – actress, Pulp Fiction, Kill Bill
- T. J. Thyne – actor
- Maura Tierney – actress
- Nancy Travis – actress
- Jonathan Tucker – actor
- Paige Turco – actress
- Anne Twomey – actress
- Steven Tyler – actor, musician, TV personality
- Steven Van Zandt – actor
- Donnie Wahlberg – actor and musician
- Mark Wahlberg – actor, musician, producer; Entourage, The Departed, Ted
- Nancy Walls – actress, Saturday Night Live, The Office
- Barbara Walters – television journalist and personality
- Sam Waterston – actor
- William A. Wellman – Academy Award-winning director
- Lyle R. Wheeler – Academy Award-winning art director
- Brian J. White – actor, dancer
- Kristen Wilson – actress
- Alicia Witt – actress
- Kenny Wormald – dancer, actor
- George Wyner – actor
- Greg Yaitanes – director
- Michael Yebba – actor, screenwriter
- Rob Zombie – director, screenwriter, The Devil's Rejects
Radio
- Dean Barnett – occasional fill-in radio host for Hugh Hewitt
- Liane Hansen – senior host of NPR's Weekend Edition Sunday
- Ray and Tom Magliozzi – of Car Talk
- Leslie Marshall – radio talk host
- Henry Joseph Nasiff Jr. – former Howard Stern Show regular
- Ryen Russillo – sports radio host
- Paul Sullivan – radio talk host
Hosts, sportscasters, and television personalities
- Tom Bergeron – television personality and game show host
- Michelle Bonner – ESPN SportsCenter and ESPNEWS anchor
- Susie Castillo – MTV VJ and 2003 Miss USA
- Liz Claman – anchor for Fox Business Network's Countdown to the Closing Bell
- Bertha Coombs – general assignment reporter for CNBC
- S. E. Cupp – conservative pundit and Crossfire panelist
- Fred Cusick – play-by-play announcer for the Boston Bruins
- Arwa Damon – video correspondent for CNN International and CNN based in Iraq
- Damien Fahey – MTV VJ
- Josh Gates – explorer and host of Destination Truth on Syfy network
- Ed Herlihy – radio and television announcer
- John King – CNN chief national correspondent
- Steve Kornacki – political commentator on MSNBC and host of Up
- Wayne Larrivee – play-by-play announcer for the Green Bay Packers; previously for the Chicago Bears
- Josh Lewin – play-by-play announcer for the Texas Rangers
- Sean McDonough – sports announcer for ESPN
- Maria Menounos – television presenter for Entertainment Tonight and Access Hollywood
- Katie Nolan – Emmy-winning television host for Fox Sports 1
- Dave O'Brien – ESPN sportscaster
- Lawrence O'Donnell – political commentator on MSNBC and host of The Last Word
- Don Orsillo – play-by-play announcer for the San Diego Padres
- Gil Santos – WBZ, voice of the New England Patriots
- John Sencio – host of Cash In The Attic for HGTV, MTV VJ during the 1990s, actor and musician
- George Stephanopoulos – chief political correspondent for ABC News, co-anchor of Good Morning America
- Lesley Visser – sportscaster, Boston Globe sportswriter, co-host of The NFL Today
- Suzyn Waldman – sportscaster for WCBS-AM and color commentator for the New York Yankees
- Mike Wallace – television personality and journalist, 60 Minutes correspondent
Early settlers/colonists
- Dorcas Ye Blackmore – one of the first African Americans to settle in New England
- Elizabeth Poole – founder of Taunton, in 1637; the first woman to have founded a town in the Americas
- Jonas Rice – first permanent settler and founder of Worcester
- John Murray – Athol
- Joseph Hull – Barnstable
- Roger Conant – credited with establishing the communities of Salem, Peabody, and Danvers
Literature, journalism, and philosophy
- Francis Ellingwood Abbot – philosopher and theologian
- Herbert Baxter Adams – educator, historian
- Louisa May Alcott – author, Little Women
- Horatio Alger, Jr. – author
- Amelia Atwater-Rhodes – author, In the Forests of the Night, Demon in my View
- Mike Barnicle – journalist
- Peter Beinart – journalist
- Edward Bellamy – author and socialist
- Amalie Benjamin – journalist, The Boston Globe
- James Bennet – editor-in-chief of The Atlantic
- Elizabeth Bishop – poet
- Benjamin C. Bradlee – Editor-in-chief and Vice President of the Washington Post, author, journalist
- Anne Bradstreet – poet
- Joseph Breck – author, magazine editor, publisher
- Howard Bryant, sports journalist for ESPN
- William Cullen Bryant – poet
- Augusten Burroughs – Running with Scissors
- Robert Ellis Cahill – sheriff, politician, folklorist, author, some three dozen books on New England history and lore
- John Casey – author
- Robert Cormier – author, columnist
- Bernard Cornwell – created Richard Sharpe
- Robert Creeley – poet
- E. E. Cummings – poet
- Steve Curwood – journalist, author
- Stephen Daye – printer
- Donald Davidson – philosopher
- Emily Dickinson – poet
- E. J. Dionne – liberal op-ed columnist for The Washington Post
- W. E. B. Du Bois – author, editor, historian, The Souls of Black Folk
- Andre Dubus III – author
- Will Durant – writer, historian, philosopher
- Gordon Edes – sports journalist
- Dave Eggers – author
- Ralph Waldo Emerson – poet, Nature, The Transcendentalist
- Dan Fitzpatrick – author
- George Frazier – journalist
- Robert Frost – poet
- Linda Gaboriau – dramaturg and literary translator
- Nicholas Gage – writer and journalist
- John Kenneth Galbraith – author, educator, and public official
- Peter Gammons – sportswriter
- Khalil Gibran – artist, poet, writer
- George Gilder – author, intellectual
- Ellen Goodman – journalist, syndicated columnist
- Edward Gorey – author and illustrator
- Nathaniel Hawthorne – author, The Scarlet Letter
- Nat Hentoff – historian, novelist, music critic
- George V. Higgins – columnist, author, The Friends of Eddie Coyle
- M. E. Hirsh – novelist
- Oliver Wendell Holmes, Sr. – poet and essayist
- Helen Maria Hunt Jackson – author
- Sebastian Junger – author, journalist
- Janice Kaplan – novelist, magazine editor
- Marina Keegan – author, playwright
- Jack Kerouac – author, On the Road
- Ronald Kessler – journalist, author, In the President's Secret Service
- Richard Kindleberger – reporter, editor, The Boston Globe
- Peter King – sportswriter, author
- Jonathan Kozol – author, educator, activist
- Stanley Kunitz – poet, Poet Laureate of the United States
- Peter Laird – comic book creator of the Teenage Mutant Ninja Turtles
- Timothy Leary – psychologist, author, Turn On, Tune In, Drop Out
- Dennis Lehane – author
- Mark Leibovich – journalist and author, The New Imperialists
- Henry Cabot Lodge – author and public official
- Henry Wadsworth Longfellow – author
- Amy Lowell – Pulitzer Prize-winning poet
- James Russell Lowell – poet
- Robert Lowell – poet
- Michael Patrick MacDonald – author, activist, All Souls
- William Manchester – author and biographer
- William Marston – comic book writer, co-created Wonder Woman
- Tony Massarotti – sportswriter, The Boston Globe
- Stephen McCauley – The Object of My Affection
- Will McDonough – sportswriter for the Boston Globe
- Eileen McNamara – columnist, The Boston Globe
- Susan Minot – novelist, short story writer
- Robin Moore – author, The Green Berets
- Orson Desaix Munn – publisher of Scientific American
- Marvin Olasky – author, editor-in-chief of WORLD Magazine
- Charles Olson – poet
- Robert B. Parker – author
- Bliss Perry – literary critic, writer, editor
- Maude Gillette Phillips – author, educator
- Charlie Pierce – sportswriter, political blogger, author
- Daniel Pipes – author,
- Sylvia Plath – poet, author, and essayist, The Bell Jar
- Edgar Allan Poe – author and poet, "The Raven", "The Fall of the House of Usher"
- Rufus Porter – founder of Scientific American magazine
- Douglas Preston – author, The Book of the Dead
- John Rennie – editor-in-chief of Scientific American magazine
- Bob Ryan – sportswriter for The Boston Globe
- R.A. Salvatore – author
- George Santayana – philosopher, essayist, poet, novelist, The Life of Reason
- Daniel Scott – author, Some of Us Have to Get Up in the Morning, Pay This Amount
- Horace Scudder – man of letters, editor
- Dr. Seuss – born Theodor Seuss Geisel, author, poet and illustrator
- Anne Sexton – poet
- Mark Shasha – author
- Dan Shaughnessy – sportswriter
- Anita Shreve – author
- Kyle Smith – film critic, novelist, essayist
- Jeff Stein – columnist
- Lothrop Stoddard – political scientist, historian, journalist, anthropologist, eugenicist
- Sabrina Tavernise – journalist
- Michelle Tea – Rent Girl
- Henry David Thoreau – philosopher, author, Walden
- John Updike – author
- Edith Wharton – author
- Phillis Wheatley – first African-American woman to publish a book of poetry
- John Greenleaf Whittier – poet and abolitionist
- Thomas E. Woods, Jr. – author, historian
- Jane Yolen – author
Military
- Clarence Lionel Adcock – US Army, deputy to General Lucius D. Clay in 1946
- Nathaniel M. Allen – soldier in Civil War, awarded Medal of Honor
- George Bancroft – Secretary of the Navy and founder of the US Naval Academy
- William Francis Buckley – US Army officer and CIA operative; died in 1985 while being tortured by the Islamist group Hezbollah
- William Harvey Carney – African-American soldier in Civil War
- George W. Casey, Jr. – US Army general and Chief of Staff of the United States Army
- Christopher Cassidy – US Navy SEAL, NASA astronaut
- David Cohen - a member of the US Army, a liberator of the Ohrdruf concentration camp, and a schoolteacher
- Joseph Dunford – United States Marine Corps general, Chairman of the Joint Chiefs of Staff under Barack Obama
- John Wesley Emerson – Civil War commander
- General John Galvin – retired US Army; former dean of The Fletcher School at Tufts University
- Adolphus Greely – Polar explorer, US Army officer and recipient of the Medal of Honor
- Joseph Hooker – commander of the Army of the Potomac in the Civil War
- Cyprian Howe – colonel in the American Revolutionary War
- Joseph P. Kennedy Jr. – US Navy lieutenant, killed in action during World War II
- Henry Knox – officer in the Continental Army, 1st United States Secretary of War
- Barry McCaffrey – four-star Army General, Director of the Office of National Drug Control Policy
- George Patton IV – major general in the U.S. Army
- Israel Putnam – major general in the American Revolutionary War
- Elmer J. Rogers, Jr. – United States Air Force lieutenant general
- Andrew Jackson Smith – African-American soldier in the Civil War
- Robert Gould Shaw – US officer in Union Army, commanded the 54th Massachusetts Infantry Regiment
- Charles Pomeroy Stone – soldier, explorer, and engineer
- Ralph Talbot – United States Marine Corps pilot during World War I, Medal of Honor
- Steven N. Wickstrom – Army National Guard Major General who commanded the 42nd Infantry Division
- Timothy Bigelow – Revolutionary War patriot
Music
Classical music
- John Coolidge Adams – composer
- Samuel Adler – composer and conductor, lived and studied for a time in Massachusetts before moving to New York
- Leroy Anderson – composer of short, light concert pieces
- Leonard Bernstein – conductor, composer, author, music lecturer and pianist of Ukrainian Jewish descent
- Sarah Caldwell – opera conductor, impresario and stage director of opera
- Michael Gandolfi – composer of contemporary classical music
- Serge Koussevitzky – born in Russia, composer and conductor Boston Symphony Orchestra; professor to Leonard Bernstein, Samuel Adler and Sarah Caldwell
- Walter Piston – composer, music theorist and professor of Italian-American descent
- Roger Sessions – composer, critic and teacher
- Randall Thompson – composer of choral works
Other music
- Akrobatik – rapper
- Bell Biv Devoe – R&B group
- Nuno Bettencourt – singer and guitarist of Extreme
- Tracy Bonham – alternative rock musician
- Bobby Brown – singer
- Michael Burkett – singer, bassist of NOFX and owner of Fat Wreck Chords, born in Massachusetts
- Gary Cherone – rock singer and songwriter
- Roderick Chisholm – philosopher
- Neil Cicierega – singer and internet cult icon
- Ray Conniff – easy-listening recording artist
- Cousin Stizz – rapper, Dorchester
- Rich Cronin – singer, LFO
- Danny Davis – country musician
- Brad Delp – lead singer of former bands Boston, RTZ
- Nicole Fiorentino – bass guitarist of The Smashing Pumpkins
- John Flansburgh – half of They Might Be Giants
- Thom Gimbel – rhythm guitar, saxophone, flute, keyboards, vocals for Foreigner
- Barry Goudreau – guitars, backing vocals for Boston, RTZ, Ernie and the Automatics
- Norman Greenbaum – singer
- Tom Hamilton – bassist for Aerosmith
- Kay Hanley – singer
- Sib Hashian – drums, percussion, backing vocals for Boston, RTZ, Ernie and the Automatics
- Juliana Hatfield – guitarist, singer-songwriter
- Roy Haynes – jazz musician
- Pete Francis Heimbold – Dispatch member
- JoJo – singer
- Sonya Kitchell – singer-songwriter
- Joey Kramer – drummer for Aerosmith
- Jordan Knight – singer-songwriter
- Phil Labonte – singer, All That Remains
- Jack Landrón – folk singer, songwriter
- Aaron Lewis – lead vocalist and rhythm guitarist of Staind
- John Linnell – one half of They Might Be Giants
- Mary Lou Lord – singer, guitarist
- Joyner Lucas – rapper
- Taj Mahal – blues musician
- J Mascis – singer-songwriters, guitarist for Dinosaur Jr
- Jonah Matranga – singer/songwriter
- Andrew McMahon – singer, pianist
- Jo Dee Messina – country artist
- Angie Miller – singer, songwriter
- Mike Ness – guitarist, vocalist, songwriter for Social Distortion
- Taecyeon Ok – actor, model, and member of South Korean pop group 2PM
- Joe Perry – guitarist, singer for Aerosmith, The Joe Perry Project
- Linda Perry – singer-songwriter
- Bobby "Boris" Pickett – singer
- Rachel Platten – singer-songwriter
- Ruth Pointer – singer-songwriter of the Pointer Sisters
- Alisan Porter – singer-songwriter and retired actress; winner of The Voice season 10
- Jonathan Richman – singer-songwriter in The Modern Lovers
- David Robinson – drummer, The Cars
- Tom Scholz – musician, composer for the band Boston
- Carly Simon – musician, singer, composer
- Slaine – hip-hop MC
- Spider One – singer
- Billy Squier – rock musician
- Quinn Sullivan – guitarist, singer
- Donna Summer – singer-songwriter
- James Taylor – singer-songwriter, instrumentalist
- Meghan Trainor – singer-songwriter
- Chad Stokes Urmston – Dispatch member
- Brad Whitford – singer, guitarist for Aerosmith
- Alan Wilson – guitarist and singer for the band Canned Heat
- Rob Zombie – singer, director
Native Americans
- King Philip – war chief
- Crispus Attucks
- Samoset – first Native American to make contact with the Pilgrims
- Squanto – helped the Pilgrims in their first visit to the New World
- Caleb Cheeshahteaumuck – first Native American graduate of Harvard University
- Passaconaway – Chief of the Pennacook tribe
- Massasoit – Chief of the Wampanoag tribe in 1621
People involved in the American Revolution
- John Adams – Patriot; 2nd President and 1st Vice President of the United States
- Samuel Adams – 4th Governor of Massachusetts and Delegate to the Continental Congress
- Crispus Attucks – first casualty of the American Revolutionary War
- Edward Bancroft – physician and spy for both the U.S. and Britain during the Revolution
- Benjamin Church – first Surgeon General of the United States Army
- Isaac Davis – commanded Minutemen during Battles of Lexington and Concord, logo of the National Guard
- Thomas Dawes – colonel in Massachusetts militia
- William Dawes – rode with Paul Revere during "Midnight Ride"
- William Eustis – physician, military surgeon at Battle of Bunker Hill, 12th Governor of Massachusetts
- John Glover – Brigadier General in the Continental Army
- John Hancock – 1st and 3rd Governor of Massachusetts and President of the Continental Congress
- James Otis – lawyer; known for his catchphrase "No taxation without representation"
- Robert Treat Paine – signer of the Declaration of Independence and 1st Attorney General of Massachusetts
- John Parker – farmer, minuteman during the Battles of Lexington and Concord
- Samuel Prescott – only participant of "Midnight Ride" to reach Concord
- William Prescott – Colonel during the Battle of Bunker Hill
- Josiah Quincy II – Boston lawyer
- Paul Revere – silversmith; Patriot; known for his "Midnight Ride"
- Deborah Sampson – disguised herself as a man in the Continental Army
- Artemus Ward – Major general in the American Revolution; Congressman from Massachusetts
- Joseph Warren – physician; President of the Massachusetts Provincial Congress
- Mercy Otis Warren – political writer and propagandist of the American Revolution
- Timothy Bigelow – Patriot, colonel of the 15th Massachusetts Regiment of the Continental Army
Politics and government
Presidents
- John Adams – 2nd President of the United States
- John Quincy Adams – 6th President of the United States
- George H. W. Bush – 41st President of the United States
- Calvin Coolidge – 30th President of the United States
- John F. Kennedy – 35th President of the United States
Vice Presidents
- John Adams – 1st Vice President of the United States
- George H. W. Bush – 43rd Vice President of the United States
- Calvin Coolidge – 29th Vice President of the United States
- Elbridge Gerry – 5th Vice President of the United States
- Henry Wilson – 18th Vice President of the United States
Governors
- Samuel Adams – 4th Governor of Massachusetts and Delegate to the Continental Congress
- Charlie Baker – 72nd Governor of Massachusetts
- James Bowdoin – 2nd Governor of Massachusetts
- Paul Cellucci – 69th Governor of Massachusetts and U.S. Ambassador to Canada
- James Michael Curley – 35th Mayor of Boston and 53rd Governor of Massachusetts
- Calvin Coolidge – 48th Governor of Massachusetts
- Michael Dukakis – 65th and 67th Governor of Massachusetts and 1988 Democratic presidential nominee
- Edward Everett – 15th Governor of Massachusetts; U.S. Secretary of State; remembered for his two-hour speech at Gettysburg
- Elbridge Gerry – 9th Governor of Massachusetts
- John Hancock – 1st and 3rd Governor of Massachusetts and President of the Continental Congress
- Thomas Hutchinson – Colonial Governor
- Levi Lincoln Sr. – U.S. Attorney General, U.S. Secretary of State and Governor of Massachusetts
- Deval Patrick – 71st Governor of Massachusetts
- Mitt Romney – 70th Governor of Massachusetts, 2012 Republican presidential nominee
- Jane Swift – first and only female Governor of Massachusetts
- John A. Volpe – U.S. Secretary of Transportation under President Nixon and 61st and 63rd Governor of Massachusetts
- David I. Walsh – U.S. Senator and 46th Governor of Massachusetts
- Bill Weld – 68th Governor of Massachusetts, 2016 Libertarian Vice-Presidential nominee
Senators
- Edward Brooke – U.S. Senator from Massachusetts; first African-American popularly elected to the Senate
- Henry L. Dawes – U.S. Senator from Massachusetts; notable for the Dawes Act
- Paul Douglas – U.S. Senator from Illinois
- John F. Kennedy – U.S. Senator and Congressman from Massachusetts
- Robert F. Kennedy – U.S. Attorney General and U.S. Senator from New York
- Ted Kennedy – longtime U.S. Senator from Massachusetts
- John Kerry – U.S. Senator from Massachusetts, U.S. Secretary of State, and 2004 Democratic presidential nominee
- Henry Cabot Lodge – U.S. Senator from Massachusetts, led the Senate opposition to the League of Nations
- Henry Cabot Lodge, Jr. – U.S. Senator Massachusetts and 1960 Republican Vice-Presidential nominee
- Ed Markey – U.S. Senator from Massachusetts and former Congressman
- Warren Rudman – U.S. Senator from New Hampshire
- Leverett Saltonstall – U.S. Senator and 55th Governor of Massachusetts
- Theodore Sedgwick – U.S. Senator from Massachusetts and Speaker of the U.S. House of Representatives
- Roger Sherman – U.S. Senator from Connecticut and delegate to Continental Congress; signer of Declaration of Independence, Articles of Confederation, and U.S. Constitution
- Charles Sumner – U.S. Senator from Massachusetts; notable leader of the Radical Republicans
- John E. Sununu – U.S. Senator from New Hampshire
- Paul Tsongas – U.S. Senator from Massachusetts and 1992 Democratic presidential candidate
- Elizabeth Warren – U.S. Senator from Massachusetts and 2020 Democratic presidential candidate
- Daniel Webster – U.S. Senator and Congressman from Massachusetts, and U.S. Secretary of State
- Henry Wilson – U.S. Senator from Massachusetts
Other politicians
- Joe Arpaio – sheriff of Maricopa County, Arizona
- William M. Bulger – former President of the Massachusetts State Senate and former president of the University of Massachusetts
- Andrew Card – Massachusetts state legislator, U.S. Secretary of Transportation, White House Chief of Staff
- P.J. Crowley – Assistant Secretary of State for Public Affairs under President Obama
- Susan Davis – U.S. Congresswoman from California
- Bill de Blasio – 109th Mayor of New York City
- Thomas Finneran – Speaker of the Massachusetts House of Representatives
- John F. Fitzgerald – U.S. Congressman from Massachusetts, 38th and 40th Mayor of Boston; maternal grandfather of President John F. Kennedy
- Richard Goodwin – speechwriter for John F. Kennedy, Lyndon B. Johnson, and Robert F. Kennedy; congressional investigator
- Nathaniel Gorham – Massachusetts delegate and 6th President of the Continental Congress
- Tim Hickey – Deputy State Treasurer of Massachusetts
- John F. Kelly – U.S. Secretary of Homeland Security under President Donald Trump
- Jean Kennedy Smith – U.S. Ambassador to Ireland
- Joseph P. Kennedy II – U.S. Congressman from Massachusetts
- Joseph P. Kennedy III – U.S. Congressman from Massachusetts
- Patrick J. Kennedy – U.S. Congressman from Rhode Island
- P. J. Kennedy – member of the Massachusetts state legislature
- Harold Hongju Koh – Legal Adviser of the Department of State under President Obama
- Gina McCarthy – EPA Administrator under President Obama
- John W. McCormack – longtime U.S. Congressman from Massachusetts and Speaker of the United States House of Representatives
- Thomas Menino – longest-serving Mayor of Boston
- Ernest Moniz – U.S. Secretary of Energy under President Obama
- Tip O'Neill – longtime U.S. Congressman from Massachusetts and Speaker of the United States House of Representatives
- Peter R. Orszag – Director of the Office of Management and Budget under President Obama
- Frances Perkins – U.S. Secretary of Labor ; first woman appointed to the U.S. Cabinet
- Timothy Pickering – U.S. Secretary of State, Massachusetts politician, soldier in Continental Army in the American Revolution
- Cass Sunstein – Administrator of the White House Office of Information and Regulatory Affairs under President Obama
First Ladies
- Abigail Adams – First Lady of the United States
Lawyers and jurists
- F. Lee Bailey – criminal defense attorney; member of the "Dream Team"
- Martha Coakley – former Massachusetts Attorney General, U.S Senate candidate
- Caleb Cushing – former U.S. Attorney General
- William Cushing – one of the original Associate Justices of the U.S. Supreme Court
- Charles Devens – former U.S. Attorney General, Union Army commander in the Civil War
- Charles Garry − civil rights attorney
- Horace Gray – former Associate Justice of the U.S. Supreme Court; Chief Justice of Massachusetts Supreme Court
- Maura Healey – Massachusetts Attorney General
- Oliver Wendell Holmes Jr. – former Associate Justice of the U.S. Supreme Court; Chief Justice of Massachusetts Supreme Court; known for "Clear and present danger" opinion in Schenck v. United States
- Michael LeMoyne Kennedy − lawyer, businessman, and political activist in Massachusetts
- Robert F. Kennedy Jr. − environmentalist and lawyer
- David Kris – Assistant Attorney General under President Obama
- William Henry Moody – former Associate Justice of the U.S. Supreme Court; U.S. Attorney General; U.S. Secretary of the Navy
- James Otis Jr. – lawyer; known for his catchphrase "No taxation without representation"
- Irving Picard – attorney in the Madoff scandal
- Josiah Quincy II – Boston lawyer
- Elliot Richardson – U.S. Attorney General during Nixon administration; former Massachusetts Attorney General
- Joseph Story – former Associate Justice of the U.S. Supreme Court
- Webster Thayer – justice on the Massachusetts Superior Court, best known for Sacco and Vanzetti trial
- Kathleen Kennedy Townsend – Boston lawyer; Lieutenant Governor of Maryland
Religion
- Richard Alpert – spiritual teacher
- Russell Conwell – Baptist minister, orator, philanthropist, lawyer, and writer
- Mary Dyer – martyr
- Mary Baker Eddy – founder of Christian Science
- Ralph Waldo Emerson – Unitarian and Transcendentalist
- Louis Farrakhan – Nation of Islam leader
- Mary H. Graves – Unitarian minister, literary editor, writer
- Edward Everett Hale – religious leader
- John Harvard – clergyman and namesake of Harvard University
- Bernard Francis Law – archbishop and cardinal
- Emmanuel Lemelson – Greek Orthodox priest, investor and philanthropist
- Cotton Mather – minister
- Increase Mather – minister
- Dwight Lyman Moody – evangelist, founder of the Northfield Mount Hermon School
- Edmund Sears – Unitarian parish minister who penned "It Came upon the Midnight Clear" in 1849
- Samuel Webber – clergyman, mathematician, and academic
Science, engineering, and medicine
- Cyrus Alger – metallurgist, arms manufacturer and inventor
- Ethan Allen – co-inventor of the single-action revolver
- Johnny Appleseed – pioneer nurseryman
- Jerome Apt – astronaut
- Nima Arkani-Hamed – theoretical physicist
- Elliot Aronson – psychologist
- Charlotte Barnum – mathematician
- Clara Barton – nurse, founder of the American Red Cross
- Florence Bascom – Geologist, first woman to graduate with a Ph.D. from Johns Hopkins, started geology department at Bryn Mawr
- Alexander Graham Bell – inventor
- Sir Tim Berners-Lee – World Wide Web; MIT professor
- Ephraim Wales Bull – cultivator of the Concord grape
- Luther Burbank – horticulturist
- William Burt – inventor, surveyor, and millwright
- Vannevar Bush – engineer, inventor and science administrator
- Rachel Fuller Brown – chemist
- Noam Chomsky – linguist
- Michael Cohen – first doctor to diagnose Proteus syndrome
- Morris Cohen – metallurgist
- William D. Coolidge – physicist
- Elias James Corey – chemist, Nobel Prize in Chemistry 1990
- Jeff Corwin – biologist, wildlife conservationist, and television personality
- William Healey Dall – naturalist, malacologist
- Daniel Dennett – cognitive scientist and philosopher
- Benjamin Franklin – scientist, diplomat, public official
- Buckminster Fuller – architect, systems theorist, author, designer, and inventor
- Robert Goddard – inventor
- Ward Goodenough – anthropologist
- Charles Goodyear – inventor
- Temple Grandin – doctor of animal science and professor at Colorado State University
- Sylvester Graham – inventor
- Crawford Greenewalt – chemical engineer
- Frederick Hauck – NASA astronaut
- Elias Howe – inventor
- Dan Itse – chemical engineer and New Hampshire public official
- Melvin Johnson – prominent firearms designer
- Richard Karp – computer scientist, computational theorist
- Alan Kay – computer scientist
- Nathaniel S. Keith – manufacturer, chemist, inventor, and electrical engineer
- Robert Lanza – medical doctor, scientist
- Lewis Howard Latimer – inventor and draftsman
- Erasmus Darwin Leavitt, Jr. – mechanical engineer
- Henrietta Swan Leavitt – astronomer
- Gilbert N. Lewis – physical chemist, discovered covalent bonds
- Robert Lindsay – physicist, specializing in acoustics
- Richard Lindzen – atmospheric physicist
- Arthur Little – chemist and chemical engineer
- Percival Lowell – astronomer
- Elizabeth Marston – psychologist, co-creator of Wonder Woman
- William Marston – psychologist, co-creator of Wonder Woman
- John McCarthy – computer scientist, cognitive scientist
- Albert Abraham Michelson – physicist, first American to receive the Nobel Prize in science
- Maria Mitchell – first U.S. female astronomer
- Samuel Morse – painter, co-developer of Morse code
- William T.G. Morton – dentist and physician
- Richard Muther – industrial engineer
- Lloyd Ohlin – sociologist and criminologist
- Robert T. Paine – ecologist
- Charles Sanders Peirce – logician, mathematician, philosopher, and scientist
- Jacob Perkins – inventor, mechanical engineer and physicist
- Gregory Pincus – scientist, developed birth control pill
- Rufus Porter – inventor
- Cornelius Rhoads – pathologist and oncologist
- Albert Sacco – chemical engineer and payload specialist for NASA
- John Henry Schwarz – theoretical physicist
- Samuel Scudder – entomologist and palaeontologist
- Andrew Strominger – theoretical physicist
- Benjamin Thompson – physicist and inventor
- Edward Thorndike – psychologist
- Janice E. Voss – engineer, NASA astronaut
- An Wang – inventor, computer engineer, co-founder of Wang Laboratories
- Worcester Warner – mechanical engineer, astronomer
- Samuel Wellman – inventor of the crucible steel furnace
- David Ames Wells – engineer, textbook author, economist
- Daniel Wesson – firearms designer
- Charles Abiathar White – geologist, paleontologist
- Frank C. Whitmore – chemist
- Eli Whitney – inventor
- Kenneth G. Wilson – theoretical physicist
- John Winthrop – mathematician, physicist, astronomer
- Robert Wood – physicist, inventor
- Sewall Wright – geneticist
Others
- Henry Adams – historian
- Lillian Asplund – last survivor of the RMS Titanic who remembered the actual sinking
- Nathaniel Bowditch – mathematician
- Isaac Greenwood – mathematician
- Kevin Hassett – economist, specializing in macroeconomics and tax policy
- John Kneller – English-American professor and fifth President of Brooklyn College
- Jill Lepore – historian
- Corey Lewandowski – campaign manager for Donald Trump's 2016 presidential campaign
- Carroll Quigley – historian and theorist of the evolution of civilizations
- Acharya S – internet personality, conspiracy theorist
- Monroe and Isabel Smith – co-founders of American Youth Hostels