List of number-one Billboard Top Latin Songs of 2010
The Billboard Hot Latin Songs chart ranks the best-performing Spanish-language singles in the United States. Published by Billboard magazine, the data are compiled by Nielsen SoundScan based collectively on each single's weekly physical and digital sales, and airplay.
Chart history
| Issue date | Song | Artist | Ref. |
| January 2 | "Me Gusta Todo de Tí" | Banda El Recodo | |
| January 9 | "Me Gusta Todo de Tí" | Banda El Recodo | |
| January 16 | "Me Gusta Todo de Tí" | Banda El Recodo | |
| January 23 | "Dile al Amor" | Aventura | |
| January 30 | "Dile al Amor" | Aventura | |
| February 6 | "Se Me Va la Voz" | Alejandro Fernández | |
| February 13 | "Dile al Amor" | Aventura | |
| February 20 | "Dile al Amor" | Aventura | |
| February 27 | "Dile al Amor" | Aventura | |
| March 6 | "Dile al Amor" | Aventura | |
| March 13 | "Dile al Amor" | Aventura | |
| March 20 | "Ando Bien Pedo" | Banda Los Recoditos | |
| March 27 | "Ando Bien Pedo" | Banda Los Recoditos | |
| April 3 | "Dile al Amor" | Aventura | |
| April 10 | "Dile al Amor" | Aventura | |
| April 17 | "Me Gusta Todo de Tí" | Banda El Recodo | |
| April 24 | "Ando Bien Pedo" | Banda Los Recoditos | |
| May 1 | "Ando Bien Pedo" | Banda Los Recoditos | |
| May 8 | "Niña Bonita" | Chino & Nacho | |
| May 15 | "Niña Bonita" | Chino & Nacho | |
| May 22 | "Niña Bonita" | Chino & Nacho | |
| May 29 | "Guapa" | Diego Torres | |
| June 5 | "Bachata en Fukuoka" | Juan Luis Guerra | |
| June 12 | "Cuando Me Enamoro" | Enrique Iglesias featuring Juan Luis Guerra | |
| June 19 | "Cuando Me Enamoro" | Enrique Iglesias featuring Juan Luis Guerra | |
| June 26 | "Cuando Me Enamoro" | Enrique Iglesias featuring Juan Luis Guerra | |
| July 3 | "Cuando Me Enamoro" | Enrique Iglesias featuring Juan Luis Guerra | |
| July 10 | "Cuando Me Enamoro" | Enrique Iglesias featuring Juan Luis Guerra | |
| July 17 | "Cuando Me Enamoro" | Enrique Iglesias featuring Juan Luis Guerra | |
| July 24 | "Cuando Me Enamoro" | Enrique Iglesias featuring Juan Luis Guerra | |
| July 31 | "Cuando Me Enamoro" | Enrique Iglesias featuring Juan Luis Guerra | |
| August 7 | "Cuando Me Enamoro" | Enrique Iglesias featuring Juan Luis Guerra | |
| August 14 | "Cuando Me Enamoro" | Enrique Iglesias featuring Juan Luis Guerra | |
| August 21 | "Cuando Me Enamoro" | Enrique Iglesias featuring Juan Luis Guerra | |
| August 28 | "Cuando Me Enamoro" | Enrique Iglesias featuring Juan Luis Guerra | |
| September 4 | "Yerbatero" | Juanes | |
| September 11 | "Cuando Me Enamoro" | Enrique Iglesias featuring Juan Luis Guerra | |
| September 18 | "Cuando Me Enamoro" | Enrique Iglesias featuring Juan Luis Guerra | |
| September 25 | "Cuando Me Enamoro" | Enrique Iglesias featuring Juan Luis Guerra | |
| October 2 | "Cuando Me Enamoro" | Enrique Iglesias featuring Juan Luis Guerra | |
| October 9 | "Cuando Me Enamoro" | Enrique Iglesias featuring Juan Luis Guerra | |
| October 16 | "Niña de Mi Corazón" | La Arrolladora Banda El Limón | |
| October 23 | "Niña de Mi Corazón" | La Arrolladora Banda El Limón | |
| October 30 | "Niña de Mi Corazón" | La Arrolladora Banda El Limón | |
| November 6 | "Loca" | Shakira featuring El Cata | |
| November 13 | "Danza Kuduro" | Don Omar & Lucenzo | |
| November 20 | "Danza Kuduro" | Don Omar & Lucenzo | |
| November 27 | "Danza Kuduro" | Don Omar & Lucenzo | |
| December 4 | "Danza Kuduro" | Don Omar & Lucenzo | |
| December 11 | "Danza Kuduro" | Don Omar & Lucenzo | |
| December 18 | "Danza Kuduro" | Don Omar & Lucenzo | |
| December 25 | "Danza Kuduro" | Don Omar & Lucenzo |