List of UK Dance Singles Chart number ones of 1999
These are The Official UK Charts Company UK Dance Chart number one hits of 1999.
| Issue date | Song | Artist |
| 2 January | "What Ya Got 4 Me" | Signum |
| 9 January | "1999" | Prince |
| 16 January | "Praise You" | Fatboy Slim |
| 23 January | "Cassius 1999" | Cassius |
| 30 January | "Greece 2000" | Three Drives |
| 6 February | "You Don't Know Me" | Armand Van Helden |
| 13 February | "Can't Get Enough" | Soulsearcher |
| 20 February | "Protect Your Mind " | DJ Sakin & Friends |
| 27 February | "What U Do" | Colours featuring Stephen Emmanuel & Eska |
| 6 March | "Warhead/DNA" | Krust/Bio Mechanics |
| 13 March | "Playing with Knives" | Bizarre Inc |
| 20 March | "Bambatta" | Shy FX |
| 27 March | "Everybody Get Up" | Capriccio |
| 3 April | "Flat Beat" | Mr Oizo |
| 10 April | "Turn Around" | Phats & Small |
| 17 April | "Funk on Ah Roll" | James Brown |
| 24 April | "Taboo" | Glamma Kid featuring Shola Ama |
| 1 May | "Red Alert" | Basement Jaxx |
| 8 May | "Red Alert" | Basement Jaxx |
| 15 May | "Big Love" | Pete Heller |
| 22 May | "What You Need" | Powerhouse featuring Duane Harden |
| 29 May | "Sweet Like Chocolate" | Shanks & Bigfoot |
| 5 June | "Saltwater" | Chicane featuring Maire Brennan |
| 12 June | "Hey Boy Hey Girl" | Chemical Brothers |
| 19 June | "Hey Boy Hey Girl" | Chemical Brothers |
| 26 June | "Cream" | Blank & Jones |
| 3 July | "9 PM " | ATB |
| 10 July | "9 PM " | ATB |
| 17 July | "9 PM " | ATB |
| 24 July | "Synth & Strings" | Yomanda |
| 31 July | "Better Off Alone" | Alice Deejay |
| 7 August | "Straight from the Heart" | Doolally |
| 14 August | "Rendez-Vu" | Basement Jaxx |
| 21 August | "Rendez-Vu" | Basement Jaxx |
| 28 August | "1999" | Binary Finary |
| 4 September | "Sing It Back" | Moloko |
| 11 September | "The Launch" | DJ Jean |
| 18 September | "Afrika Shox" | Leftfield |
| 25 September | "Toca Me" | Fragma |
| 2 October | "Destination Sunrise" | Balearic Bill |
| 9 October | "The Awakening" | York |
| 16 October | "B with U" | Junior Sanchez featuring Dajae |
| 23 October | "Out of Control" | Chemical Brothers |
| 30 October | "In and Out of My Life" | Onephatdeeva |
| 6 November | "Buddy X 99" | Dreem Teem vs. Neneh Cherry |
| 13 November | "Bullet in the Gun" | Planet Perfecto |
| 20 November | "Another Way" | Paul Van Dyk |
| 27 November | "King of My Castle" | Wamdue Project |
| 4 December | "Back in My Life" | Alice Deejay |
| 11 December | "Re-Rewind " | Artful Dodger |
| 18 December | "Barber's Adagio for Strings" | William Orbit |
| 25 December | "A Little Bit of Luck" | DJ Luck & MC Neat |