First Ladies of Maryland
The spouse of the governor of Maryland is given an honorary position, styled as First Lady or First Gentleman of the State of Maryland. To date there have been no female governors of the State of Maryland, and all first spouses have been first ladies.
| Name | Took Office | Left Office | Spouse Of |
| Ann Jennings Johnson | 1777 | 1779 | Thomas Johnson |
| Mary Digges Lee | 1779 | 1782 | Thomas Sim Lee |
| Anna Maria Tilghman Chew | 1782 | 1785 | William Paca |
| none | 1785 | 1788 | William Smallwood |
| Peggy Chew Howard | 1788 | 1791 | John Eager Howard |
| none | 1791 | 1792 | George Plater |
| Juliana Jennings Brice | 1792 | 1792 | James Brice |
| Mary Digges Lee | 1792 | 1794 | Thomas Sim Lee |
| Anne Couden Stone | 1794 | 1797 | John Hoskins Stone |
| Margaret Campbell Henry | 1797 | 1798 | John Henry |
| Henrietta Margaret Hill Ogle | 1798 | 1801 | Benjamin Ogle |
| Sophia Sprigg Mercer | 1801 | 1803 | John Francis Mercer |
| Priscilla Mackall Bowie | 1803 | 1806 | Robert Bowie |
| Elizabeth Harriot Robertson Wright | 1806 | 1809 | Robert Wright |
| Sally Scott Murray Lloyd | 1809 | 1811 | Edward Lloyd |
| Priscilla Mackall Bowie | 1811 | 1812 | Robert Bowie |
| Mary Stoughton Sloss Winder | 1812 | 1816 | Levin Winder |
| Priscilla Dorsey Ridgely | 1816 | 1819 | Charles Carnan Ridgely |
| Sarah Goldsborough | 1819 | 1819 | Charles Goldsborough |
| Violetta Lansdale Sprigg | 1819 | 1822 | Samuel Sprigg |
| Eliza May Stevens | 1822 | 1826 | Samuel Stevens, Jr. |
| Eleanor Lee Wallace Kent | 1826 | 1826 | Joseph Kent |
| none | 1826 | 1828 | Joseph Kent |
| Alice Contee Kent | 1828 | 1829 | Joseph Kent |
| Mary Clare Maccubbin Martin | 1829 | 1830 | Daniel Martin |
| Julianna Stevenson Carroll | 1830 | 1831 | Thomas King Carroll |
| Mary Clare Maccubbin Martin | 1831 | 1831 | Daniel Martin |
| Prudence Gough Ridgely Howard | 1831 | 1833 | George Howard |
| Elizabeth Courts Thomas | 1833 | 1836 | James Thomas |
| Mary Wallace Veazey | 1836 | 1839 | Thomas Veazey |
| Susan Orrick Sulivane Grason | 1839 | 1842 | William Grason |
| Sally Campbell Preston McDowell Thomas Miller | 1842 | 1842 | Francis Thomas |
| none | 1842 | 1845 | Francis Thomas |
| Adeline Mackubin Kent Pratt | 1845 | 1848 | Thomas Pratt |
| Sarah Maria Kerr Thomas | 1848 | 1851 | Philip Francis Thomas |
| Esther Winder Polk Lowe | 1851 | 1854 | Enoch Louis Lowe |
| Mary Tolly Dorsey Ligon | 1854 | 1858 | Thomas Watkins Ligon |
| none | 1858 | 1862 | Thomas Holliday Hicks |
| Elizabeth Kell Bradford | 1862 | 1866 | Augustus Bradford |
| Elizabeth Sherlock Swann | 1866 | 1869 | Thomas Swann |
| Alice Carter Bowie | 1869 | 1872 | Oden Bowie |
| Louisa Hollingsworth Whyte | 1872 | 1874 | William Pinkney Whyte |
| none | 1874 | 1876 | James Black Groome |
| none | 1876 | 1877 | John Lee Carroll |
| Mary Carter Thompson Carroll | 1877 | 1880 | John Lee Carroll |
| Clara Jenness Hamilton | 1880 | 1884 | William Thomas Hamilton |
| Georgine Urquhart McLane | 1884 | 1885 | Robert Milligan McLane |
| Mary Elizabeth Staplefort Lloyd | 1885 | 1888 | Henry Lloyd |
| Nannie Rider Jackson | 1888 | 1892 | Elihu Emory Jackson |
| Mary Ridgely Preston Brown | 1892 | 1895 | Frank Brown |
| Mary Ridgely Brown Lee | 1895 | 1896 | Frank Brown |
| Elizabeth Tasker Lowndes | 1896 | 1900 | Lloyd Lowndes, Jr. |
| Mary Frances Richardson Smith | 1900 | 1904 | John Walter Smith |
| Emma Nicodemus Warfield | 1904 | 1908 | Edwin Warfield |
| Lynn Shaffer Ewing | 1908 | 1912 | Austin Lane Crothers |
| Ellen Showell Goldsborough | 1912 | 1916 | Phillips Lee Goldsborough |
| Gertrude Johnson Harrington | 1916 | 1920 | Emerson Harrington |
| Elizabeth Caskie Cabell Ritchie | 1920 | 1931 | Albert Ritchie |
| none | 1931 | 1935 | Albert Ritchie |
| Edna Viola Amos Nice | 1935 | 1939 | Harry Nice |
| Eugenia Byrnes O'Conor | 1939 | 1947 | Herbert O'Conor |
| Dorothy Byron Lane | 1947 | 1951 | William Preston Lane, Jr. |
| Honolulu Claire Manzer McKeldin | 1951 | 1959 | Theodore McKeldin |
| Helen Avalynne Gibson Tawes | 1959 | 1967 | J. Millard Tawes |
| Elinor Judefind Agnew | 1967 | 1969 | Spiro Agnew |
| Barbara Oberfeld Mandel | 1969 | 1974 | Marvin Mandel |
| Jeanne Blackistone Dorsey Mandel | 1974 | 1979 | Marvin Mandel |
| Mathilde Boal Lee | 1977 | 1979 | Blair Lee III |
| Jeanne Blackistone Dorsey Mandel | 1979 | 1979 | Marvin Mandel |
| Patricia Donoho Hughes | 1979 | 1987 | Harry Hughes |
| Hilda Mae Snoops | 1987 | 1995 | William Donald Schaefer |
| Frances Hughes Glendening | 1995 | 2001 | Parris Glendening |
| none | 2001 | 2002 | Parris Glendening |
| Jennifer Crawford | 2002 | 2003 | Parris Glendening |
| Kendel Sibiski Ehrlich | 2003 | 2007 | Bob Ehrlich |
| Catherine Curran O'Malley | 2007 | 2015 | Martin O'Malley |
| Yumi Hogan | 2015 | serving | Larry Hogan |