Leucism


Leucism is a term used to describe a wide variety of conditions which result in the partial loss of pigmentation in an animal—which causes white, pale, or patchy coloration of the skin, hair, feathers, scales or cuticles, but not the eyes. It is occasionally spelled leukism. Some genetic conditions that result in a "leucistic" appearance include piebaldism, Waardenburg syndrome, vitiligo, Chédiak–Higashi syndrome, and Melanophilin mutations. Pale patches of skin, feathers, or fur can also result from injury. As the term "leucism" is used to refer to conditions with a very wide range of unrelated causes it can not be considered to be a single, specific condition.

Details

'Leucism' is often used to describe the phenotype that results from defects in pigment cell differentiation and/or migration from the neural crest to skin, hair, or feathers during development. This results in either the entire surface or patches of body surface having a lack of cells that can make pigment.
Since all pigment cell-types differentiate from the same multipotent precursor cell-type, leucism can cause the reduction in all types of pigment. This is in contrast to albinism, for which leucism is often mistaken. Albinism results in the reduction of melanin production only, though the melanocyte is still present. Thus in species that have other pigment cell-types, for example xanthophores, albinos are not entirely white, but instead display a pale yellow colour.
More common than a complete absence of pigment cells is localized or incomplete hypopigmentation, resulting in irregular patches of white on an animal that otherwise has normal colouring and patterning. This partial leucism is known as a "pied" or "piebald" effect; and the ratio of white to normal-coloured skin can vary considerably not only between generations, but between different offspring from the same parents, and even between members of the same litter. This is notable in horses, cows, cats, dogs, the urban crow and the ball python but is also found in many other species.
Due to the lack of melanin production in both the retinal pigmented epithelium and iris, those affected by albinism sometimes have pink pupil due to the underlying blood vessels showing through. However, this is not always the case and many albino animals do not have pink pupils. The common belief that all albinos have pink pupils results in many albinos being incorrectly labeled as 'leucistic'. The neural crest disorders that cause leucism do not result in pink pupils and therefore most leucistic animals have normally coloured eyes. This is because the melanocytes of the RPE do not derive from the neural crest. Instead, an out-pouching of the neural tube generates the optic cup that, in turn, forms the retina. As these cells are from an independent developmental origin, they are typically unaffected by the genetic cause of leucism.
Genes that, when mutated, can cause leucism include c-kit, mitf and ''EDNRB.

Etymology

The terms leucistic and leucism are derived from medical terminology. The stem leuc- is the Latin variant of leuk- from the Greek leukos meaning "white".

Examples in nature

Leucism has been noted in a number of animal species, including: