In 1970, Abramson was admitted to the State Bar of California. She began her career in the Los Angeles County Public Defender's office, where she worked for six years. She entered private practice as a defense attorney in 1976, and developed a reputation as a fierce advocate for her clients. She was twice named trial lawyer of the year by the L.A. Criminal Courts Bar Association. Over the course of her career, only one client that she represented received the death penalty - a multiple murderer named Ricky Sanders, who shot eleven people in a walk-in freezer in a Bob's Big Boy restaurant, killing four of them. In 1988, Abramson was able to obtain a verdict of manslaughter with a sentence of probation, rather than murder, for 17-year old Arnel Salvatierra, who had killed his father. Abramson argued that the father had been abusive. In 1990, Abramson won the acquittal of Dr. Khalid Parwez, "a Pakistani-born gynecologist accused of strangling and dismembering his 11-year-old son", presenting an alibi for Parwez, and arguing that Parwez's brother, who had returned to Pakistan, was the likely culprit.
The Menendez trial
Abramson gained national attention in the early 1990s, when she represented Erik Menendez in his trial for the murder of his parents, again presenting parental abuse as the defense for the crime alleged. She stirred controversy when it was revealed during the trial that she had Erik's psychiatrist delete and rewrite passages of the doctor's notes. When asked by the judge about it, she twice invoked her Fifth Amendmentright against self-incrimination, and later asserted that any discussions were protected by attorney-client privilege. As a result, an investigation was launched by the state bar. Following a three-year investigation, the state bar closed its case "after deciding that there was insufficient evidence to conclude she violated ethical rules in Menendez brothers' retrial."
Post-Menendez career
In 1997, Abramson published a book, The Defense Is Ready: Life in the Trenches of Criminal Law. In 2004, she was hired by Phil Spector, who was charged with fatally shooting actress Lana Clarkson at his suburban Alhambra, California mansion, replacing his former attorney, Robert Shapiro. She resigned from representing Spector over conflicts between them; he went on to be convicted of murder, under different counsel. She is now retired but makes public appearances from time to time.
Abramson was married to a pharmacist whom she divorced in 1969, with whom she had a daughter, Laine. She married Los Angeles Times reporter Tim Rutten, and the couple adopted a son.