Laryngitis
Laryngitis is inflammation of the larynx. Symptoms often include a hoarse voice and may include fever, cough, pain in the front of the neck, and trouble swallowing. Typically, these last under two weeks.
Laryngitis is categorised as acute if it lasts less than three weeks and chronic if symptoms last more than three weeks. Acute cases usually occur as part of a viral upper respiratory tract infection. Other infections and trauma such as from coughing are other causes. Chronic cases may occur due to smoking, tuberculosis, allergies, acid reflux, rheumatoid arthritis, or sarcoidosis. The underlying mechanism involves irritation of the vocal cords.
Concerning signs that may require further investigation include stridor, history of radiation therapy to the neck, trouble swallowing, duration of more than three weeks, and a history of smoking. If concerning signs are present the vocal cords should be examined via laryngoscopy. Other conditions that can produce similar symptoms include epiglottitis, croup, inhaling a foreign body, and laryngeal cancer.
The acute form generally resolves without specific treatment. Resting the voice and sufficient fluids may help. Antibiotics generally do not appear to be useful in the acute form. The acute form is common while the chronic form is not. The chronic form occurs most often in middle age and is more common in men than women.
Signs and symptoms
The primary symptom of laryngitis is a hoarse voice. Because laryngitis can have various causes, other signs and symptoms may vary. They can include- Dry or sore throat
- Coughing
- Frequent throat clearing
- Increased saliva production
- Dysphagia
- Sensation of swelling in the area of the larynx
- Globus pharyngeus
- Cold or flu-like symptoms
- Swollen lymph nodes in the throat, chest, or face
- Fever
- General muscle pain
- Shortness of breath, predominantly in children
Voice quality
Causes
Laryngitis can be infectious as well as noninfectious in origin. The resulting inflammation of the vocal folds results in a distortion of the sound produced there. It normally develops in response to either an infection, trauma to the vocal folds, or allergies. Chronic laryngitis may also be caused by more severe problems, such as nerve damage, sores, polyps, or hard and thick lumps on the vocal cords.Laryngitis#cite note-4|Acute
Viral
- Most acute cases of laryngitis are caused by viral infections, the most common of which tend to be rhinovirus, influenza virus, parainfluenza virus, adenovirus, coronavirus, and RSV. In patients who have a compromised immune system, other viruses such as herpes, HIV and coxsackievirus may also be potential causes.
Bacterial
- This is another major cause of acute laryngitis, and may develop in conjunction with or due to a viral infection. Common bacterial strains are; group A streptococcus, Streptococcus pneumoniae, C. diphtheriae, M. catarrhalis, Haemophilus influenzae, Bordetella pertussis, Bacillus anthracis, and M. tuberculosis. In developing countries, more unusual bacterial causes may occur such as mycobacterial and syphilitic, though these may occur in developed nations as well.
Fungal
- Laryngitis caused by fungal infection is common but not frequently diagnosed according to a review by BMJ and can account for up to 10% of acute laryngitis cases. Patients with both functioning and impaired immune systems can develop fungal laryngitis, which may develop as a result of recent antibiotic or inhaled corticosteroids use. Certain strains of fungi that may cause laryngitis include; Histoplasma, Blastomyces, Candida, and Cryptococcus and Coccidioides.
Trauma
- Often due to excessive use of the vocal folds such as excessive yelling, screaming, or singing. Though this often results in damage to the outer layers of the vocal folds, the subsequent healing may lead to changes in the physiology of the folds. Another potential cause of inflammation may be overuse of the vocal cords.Laryngitis#cite note-5| Laryngitis#cite note-6| Laryngitis#cite note-7| Laryngitis#cite note-8| Laryngitis#cite note-9| Laryngeal trauma, including iatrogenic, can also result in inflammation of the vocal cords.
Chronic
Allergies
- Findings are unclear as to whether asthma may cause symptoms commonly associated with laryngitis. Some researchers have posited that allergic causes of laryngitis are often misdiagnosed as being the result of acid reflux.
Reflux
- One possible explanation of chronic laryngitis is that inflammation is caused by gastro-oesophageal reflux, which causes subsequent irritation of the vocal folds.
Autoimmune disorders
- Approximately between 30–75% of persons with rheumatoid arthritis report symptoms of laryngitis.
- Symptoms of laryngitis are present in only 0.5–5% of people that have sarcoidosis. According to a meta-analysis by Silva et al., this disease is often an uncommon cause of laryngeal symptoms and is frequently misdiagnosed as another voice disorder.
Diagnosis
- Laryngitis following trauma: This form of laryngitis is usually identified by obtaining a case history providing information on previous phono traumatic experiences, internal trauma caused by recent procedures as well as any previous neck injuries.
- Acute viral laryngitis: This form of laryngitis is characterized by lower vocal pitch as well as hoarseness. The symptoms in this form of laryngitis are usually present for less than one week, however they can persist for 3-4 weeks. This form of laryngitis might also be accompanied by upper respiratory tract symptoms such as: sore throat, odynophagia, rhinorrhea, dyspnea, postnasal discharge, and congestion.
- Fungal laryngitis: A biopsy and culture of abnormal lesion may help confirm fungal laryngitis.
Visual diagnosis
- Redness of the laryngeal tissues
- Dilated blood vessels
- Thick, yet dry laryngal tissue
- Stiff vocal folds
- Sticky secretions between the vocal folds and nearby structures
Referral
- Difficulty swallowing
- Vocal stridor
- Ear pain
- Recent weight loss
- History of smoking
- Current or recent radiotherapy treatment
- Recent neck surgery or surgery involving endotracheal tubing
- Person is a professional voice user
Differential diagnosis
- Acute epiglottitis: This is more likely in those with stridor, drooling, and painful or trouble swallowing.
- Granulomatous laryngitis
- Pseudomyxomatous laryngitis
- Croup: This presents with a barking cough, hoarseness of voice, and inspiratory stridor.
Treatment
Vocal hygiene is very important to relieve symptoms of laryngitis. Vocal hygiene involves measures such as: resting the voice, drinking sufficient water, reducing caffeine and alcohol intake, stopping smoking and limiting throat clearing.
Acute laryngitis
In general, acute laryngitis treatment involves vocal hygiene, painkillers, humidification, and antibiotics.Viral
The suggested treatment for viral laryngitis involves vocal rest, pain medication, and mucolytics for frequent coughing. Home remedies such as tea and honey may also be helpful. Antibiotics are not used for treatment of viral laryngitis.Bacterial
may be prescribed for bacterial laryngitis, especially when symptoms of upper respiratory infection are present. However, the use of antibiotics is highly debated for acute laryngitis. This relates to issues of effectiveness, side effects, cost, and possibility of antibiotic resistance patterns. Overall, antibiotics do not appear to be very effective in the treatment of acute laryngitis.In severe cases of bacterial laryngitis, such as supraglottitis or epiglottitis, there is a higher risk of the airway becoming blocked. An urgent referral should be made to manage the airway. Treatment may involve humidification, corticosteroids, intravenous antibiotics, and nebulised adrenaline.
Fungal
Fungal laryngitis can be treated with oral antifungal tablets and antifungal solutions. These are typically used for up to three weeks and treatment may need to be repeated if the fungal infection returns.Trauma
Laryngitis caused by excessive use or misuse of the voice can be managed though vocal hygiene measures.Chronic laryngitis
Reflux
treatment primarily involves behavioural management and medication. Behavioural management involves aspects such as- Wearing loose clothing
- Eating smaller, more frequent meals
- Avoiding certain foods
When appropriate, anti-reflux surgery may benefit some individuals.