Keratolytic
Keratolytic therapy is treatment to remove warts, calluses and other lesions in which the epidermis produces excess skin. In this therapy, acid medicine, such as Whitfield's ointment or Jessner's solution are put on the lesion. Keratolytic therapy thins the skin on and around the lesion. It causes the outer layer of the skin to loosen and shed.
Keratolytics can also be used to soften keratin, a major component of the skin. This serves to improve the skin's moisture binding capacity, which is beneficial in the treatment of dry skin. Such agents include alkali, salicylic acid, urea, lactic acid, allantoin, glycolic acid, and trichloroacetic acid.
While cytostatic agents such as zinc pyrithione are first line, keratolytics can also be used in the treatment of dandruff and seborrheic dermatitis.
Sulfur and salicylic acid can also be used to effectively treat acne and cradle cap in some patients. Resorcinol is another keratolytic that is usually combined with sulfur. Urea acts as a keratolytic due to its hygroscopic property.
