Chookagian made her debut in mixed martial arts professionally on June 28, 2014 at CFFC 37. She faced Rebecca Heintzman, and was a unanimous decision winner after three rounds. Chookagian made her second professional fight at on September 13, 2014. Katlyn Chookagian secured a knockout triumph against 44-year-old Brigitte Narcise at 38 seconds of the final round in the flyweight category. Chookagian had her two subsequent bouts canceled. Against Allanna Jones in the Ring of Combat 49, and against Nohime Dennison at CFFC 45. Finally, on May 9, 2015, she fought twice in the same day, beating Linn Wennergren by unanimous decision, and Melinda Fábián by finalization in the first round. She returned to the event where she made her debut, the CFFC, and held three more fights there. The results continued great: two belts, two victories by unanimous decision and one by knockout, due to a knee.
Chookagian debuted in the UFC on July 13, 2016 at against Lauren Murphy. She won the fight via unanimous decision. Chookagian next fought Liz Carmouche at UFC 205. She lost the bout via split decision. Chookagian faced Irene Aldana at UFC 210 on April 8, 2017. She won the fight by decision. Chookagian faced Mara Romero Borella on January 27, 2018 at. She won the fight via unanimous decision. Chookagian faced Alexis Davis on July 28, 2018 at UFC on Fox 30. She won the fight by unanimous decision. Chookagian faced Jessica Eye on December 8, 2018 at UFC 231. She lost the fight by split decision.. Chookagian faced Joanne Calderwood on June 8, 2019 at UFC 238. She won the fight by unanimous decision. Chookagian faced Jennifer Maia on November 2, 2019 at UFC 244. At the weigh-ins, Maia weighted at 127.2 pounds, 1.2 pounds over the flyweight non-title fight limit of 126. The bout proceed at catchweight and Maia was fined 25% of her purse and went to Chookagian. She won the fight via unanimous decision. Chookagian faced Valentina Shevchenko for the UFC Flyweight Champion on February 8, 2020 at UFC 247. She lost the bout via technical knockout in round three. Chookagian faced Antonina ShevchenkoMay 30, 2020 at. After dominating Shevchenko on the ground throughout the bout, Chookagian won the fight via unanimous decision.
Championships and accomplishments
Ultimate Fighting Championship
*Tied for most wins in the UFC Women's Flyweight division
*Tied for the most fights in the UFC Women's Flyweight division