Kathy Niakan


Kathy Niakan is a developmental biologist, working in human developmental and stem cell biology. In 2016 she became the first scientist in the world to gain regulatory approval to edit the genomes of human embryos for research.

Biography

Kathy Niakan obtained a BSc in cell and molecular biology and a BA in English literature from the University of Washington. In 2005, Niakan obtained her PhD in stem cell and developmental biology from the University of California, Los Angeles, where she worked in the laboratory of Edward McCabe. She went on to be a research fellow with Kevin Eggan at Harvard University, working with human and mouse stem cells to study human embryogenesis and cell potency. She then moved to the University of Cambridge Anne McLaren Laboratory for Stem Cell Biology in the Cambridge Biomedical Campus where she continued to investigate the molecular basis of early cell development in humans and mice.
In 2013, Niakan became a group leader at the MRC National Institute for Medical Research in London. Since 2015, she has been a group leader at the Francis Crick Institute, the successor institute to the NIMR.
Niakin was named as one of the 100 most influential people in the world by Time magazine in April 2016. She was a finalist in the inaugorary UK Blavatnik Awards for Young Scientists in 2019.

Research

At the Francis Crick Institute she is investigating the mechanisms of lineage specification in human embryos and stem cells.
In February 2016 Niakan was given the go-ahead by the UK Human Fertilisation and Embryology Authority to genetically modify human embryos. The embryos were to be destroyed after seven days. She planned to use the CRISPR technique to answer questions like what genetic faults cause some women to miscarry, what causes infertility and what is crucial for a healthy embryo. In 2017 her lab published the first major study using CRISPR-Cas9 in human embryos in Nature, demonstrating that the transcription factor Oct4 is essential for fetal development.