She was the only child of Kona chief Naihekukui, who was commander of the native Hawaiian fleet at Honolulu. Her mother was Chiefess Iahuula, the younger sister of Charles Kanaʻina. Kanaʻina would become hānai parent of the child. Kalama means "The Torch" in the Hawaiian language.
Marriage
The young Kamehameha III, the boy king at the time, was needing a suitable royal bride. Many of the traditional chiefs wanted a union between the king and his sister Nāhienaena, as had been customary in the Hawaiian court since its beginning; however, the Christian missionaries and chiefs, who held significant political power, opposed this suggestion, calling it incest. Kamanele, the daughter of Governor John Adams Kuakini, was proposed as the most suitable in age, rank, and education. The young king fell in love with Kalama in 1832. This angered his sister Kīnaʻu and many of the high chiefs. Kamehameha III married her on February 14, 1837. This was only a few months after Nahienaena's death.
She would outlive both her husband Kamehameha III and her nephew Kamehameha IV, becoming known as the Queen dowager of Hawaii. She met Prince Alfred on his visit to Hawaii in the reign of Kamehameha V. She drove out to Waikīkī in her own carriage of state, accompanied by her adopted son, Kunuiakea, and Miriam Likelike. The drivers of these carriages wore the royal feather shoulder capes, and the footmen were clad in like royal fashion. It was considered one of the grandest occasions in the history of those days. Kalama skillfully managed her properties and at the time of her death, she owned over 22,000 acres on the windward side of the island of Oahu. In her will, her uncle Charles Kanaina was declared as the heir to her vast lands and properties. She died on September 20, 1870, in Honolulu at the age of 53. On September 21, American marines had to be landed to place the American flag at half-mast, when the American consul at Honolulu would not assume responsibility for doing so, owing to a past instance where the Queen's death was falsely reported.
Namesakes
Hakaleleponi Gate, an entrance for servants and attendants in ʻIolani Palace, is named after her.
In 1925, Harold K.L. Castle developed Kailua's first housing tract and named it Kalama after the Queen, who previously had owned the land in the Kailua area.