K-43 begins at an intersection with K-4 at the northern city limit of Hope. The highway heads north for about before turning west and entering the small community of Navarre. The route crosses the BNSF Railway and turns to the north, continuing through flat farmland. The highway crosses the railway again before entering the city ofEnterprise. In Enterprise, K-43 turns east along 5th Street, then north onto Factory Street. The highway curves northwest and crosses the BNSF Railway a third time before crossing the Smoky Hill River on a truss bridge constructed in 1924. Upon crossing this bridge, K-43 leaves Enterprise. The route bends to the north and crosses the BNSF Railway a fourth and final time. Continuing north through level plains, K-43 meets a railroad operated byUnion Pacific and comes to an intersection with its former northern terminus at an old alignment of US-40. At this intersection, the route turns to the northeast and travels through the community of Detroit before turning back to the north. North of here, K-43 meets its northern terminus at a diamond interchange with I-70 and US-40. K-43 is maintained by the Kansas Department of Transportation. The traffic numbers on the route in 2012, measured in annual average daily traffic, were relatively low compared to other state highways. Between 185 and 1900 vehicles traveled the highway each day, including between 30 and 95 trucks. The most traffic was present in the segment of the highway between Enterprise and Detroit. No segment of K-43 is included in the NationalHighway System, a system of highways considered to be important to the nation's defense, economy, and mobility.
History
K-43 first appears on the 1932 state highway map. At that time it followed largely the same alignment it does today, running from K-4 in Hope to an intersection with what was then US-40S. Most of the road was dirt, but it was paved with gravel from Enterprise north to its northern terminus. By 1936, the whole route had been upgraded to gravel pavement. In 1945, the portion north of Enterprise was paved. The entire highway had been paved by 1956. In 1962, the highway was extended slightly to the north, moving its northern terminus from US-40 to an interchange with the newly constructed I-70. The route has not changed significantly since 1962.