Scheeres came to prominence with the 2005 publication of Jesus Land, a memoir of her turbulent youth growing up rebellious in a strict fundamentalist Christian family near West Lafayette, Indiana, including a harrowing stint in a Christian "reform school" in the Dominican Republic. The memoir is centered on her relationship with her adoptive brother David, of African-American ancestry, and on their shared experiences coping with both religious and racial intolerance, in Lafayette, including at William Henry Harrison High School. Scheeres has described the genesis of the book by stating, "I knew David better than anyone. From the time he was adopted at age three until he died in a car crash at age 20, we were in constant contact. We were the same age. We shared classrooms, church youth groups, even a reform school. It fell on my shoulders to keep his memory alive. This was a heavy burden." Jesus Land was a New YorkTimes bestseller, and a Times bestseller in the UK. The book was also the winner of the American Library Association's ALex Award and the New Visions Nonfiction Book Award. The trade publication Publishers Weekly declared the book "announces the author as a writer to watch," and the Boston Globe praised it as "rough, brutal, and shockingly good." She stated in her memoir that she is no longer a Christian but a humanist. In December 2011, Escuela Caribe, the reform school featured in her memoir, was closed down due to a successful by alumni to expose its 40-year history of child abuse. The property was transferred to another Christian ministry called Crosswinds, which reopened the school under the name Caribbean Mountain Academy. Although their website states their program is not affiliated with New Horizons Youth Ministries, as of 2014 at least five staff members from Escuela Caribe remained employed at the school after the transition.
''A Thousand Lives''
In 2011, Scheeres published A Thousand Lives, an account of the Jonestown settlement and mass murder. Based on 50,000 pages of recently released FBI files and rare interviews with survivors, "A Thousand Lives" chronicles the lives of five Jonestown residents who move to the jungle utopia in 1978 only to realize that their leader, Jim Jones, was a madman bent on killing them. Scheeres broke several stories while writing the book. She learned that Jones was planning to kill his followers for five years prior to actually doing it, and that his inner circle supported his plans for a "revolutionary suicide." She also found notes and memos from the camp doctor, Larry Schacht, who struggled to find a way to kill the 900+ residents of Jonestown and experimented with botulism and other bacteria before settling on cyanide. A Thousand Lives was reviewed widely and critically acclaimed. The New York Times hailed the book as "a gripping account of how decent people can be taken in." The Los Angeles Times raved that "Scheeres convincingly portrays the members of this community as victims, not fools. It's hard to imagine how people might be so browbeaten, afraid and misled that they would bring about their own deaths—but Scheeres has made that terrifying story believable and human." There are many parallels between her two books. Both deal with race, religion, and yearnings for utopia. At present, Scheeres is working on a second memoir about her years living in Spain in the aftermath of her brother's death. She is an office-holder at the , where she teaches memoir workshops and works as a writing coach.