Solís started his professional boxing career in 1998 at 112 pounds at the age of 19. His early fights usually took place in Mexico. His first professional fight was a four-round bout against Bernardo Tule on February 6, 1998, which Solís won via technical knockout. His first fight in the United States of America was against Juan Jose Mendez on September 2, 2000 in the Don Haskins Center, El Paso, Texas, which he won in the 6th round by technical knockout. On October 27, 2001 Solís faced Ruben Estanislao for the Mexican Super Bantamweight Championship, which he won and defended it against Jorge Munoz, Sammy Ventura and Fernando Alanis. On June 6, 2003 Solis faced Wilson Alcorro for the WBC Latin America Super Featherweight Title but the bout ended in a draw. In September 2004, Solis fought future champion Humberto Soto in a bout which resulted in a "no contest" decision. Solis was knocked to the canvas by Soto in the third round, but the fight was stopped later in the round after Solis suffered a cut due to an accidental clash of heads. Humberto Soto, who was ahead on all scorecards, disputed the outcome claiming that the cut was the result of a punch and not a head clash.
Solis vs Pacquiao
On April 14, 2007, Solis faced off against reigning WBC International Super-Featherweight champion, then three-division world champion Manny Pacquiao in San Antonio, Texas. Solis provided a tougher challenge than expected, however, Pacquiao proved too much for the number four ranked challenger. Pacquiao unleashed a barrage of lethal punches to knock-out the unbeaten Solis in the eighth round. In the Philippines, this match was called as The Blaze of Glory. After being beaten by Pacquiao, Jorge defeated Santiago Allione at the Arena Coliseo in Guadalajara by Technical Knockout. On January 31, 2009 in Zapopan, Jalisco, Solís scored a fifth-round technical knockout of Monty Meza Clay in an IBF title eliminator.
Solis vs Cruz
On July 11, 2009, Solis challenged IBF featherweight champion Cristobal Cruz, whom Solis had previously defeated, but lost by unanimous decision. During the bout, Solis was docked 4 points for intentional low blows while Cruz was docked two points for headbutting. The final scores were 113-110, 113-110, and 113-111 in favor of Cruz. Solis moved up to the Super Featherweight division in his next bout and defeated Likar Ramos by 7th-round TKO to claim the WBA interim Super featherweight title. On May 8, 2010, Solis defended his interim title against Mario Santiago by a wide unanimous decision on the under-card of Latin Fury 14.
Gamboa vs Solis
On March 26, 2011, Solis got a chance to take on the Unified WBA World and IBF Featherweight ChampionYuriorkis Gamboa. Solis was completely and utterly dominated by Gamboa and was knocked out in the fourth round in what was a dazzling display of boxing skills from Gamboa.
