His father was a master tailor and when 12 he studied at the Friedrich‐Werdersche Gymnasium in Berlin. He was orphaned at age 19 by an outbreak of typhus, and found himself responsible for raising three younger sisters. He began giving academic lessons as a private tutor and in this way met Wilhelm Beer, a wealthy banker, in 1824. In 1829 Beer decided to set up a private observatory in Berlin, with a 95 mm refractor telescope made by Joseph von Fraunhofer, and Mädler worked there. In 1830 they began producing drawings of Mars which later became the first true maps of that planet. They were the first to choose what is today known as Sinus Meridiani as the prime meridian for Martian maps. They made a preliminary determination for Mars' rotation period, which was off by almost 13 seconds. A later determination in 1837 was off by only 1.1 seconds. They also produced the first exact map of the Moon, Mappa Selenographica, published in four volumes in 1834–1836. In 1837 a description of the Moon was published. Both were the best descriptions of the Moon for many decades, not superseded until the map of Johann Friedrich Julius Schmidt in the 1870s. Beer and Mädler drew the firm conclusion that the features on the Moon do not change, and there is no atmosphere or water. In 1836, Johann Franz Encke appointed Mädler an observer at the Berlin Observatory, and he observed with its 240-mm refractor. In 1840, Mädler was appointed director of the Dorpat Observatory in Estonia, succeeding Friedrich Wilhelm Struve who had moved to Pulkovo Observatory. He carried out meteorological as well as astronomical observations. He continued Struve's observations of double stars. He remained in Tartu until he retired in 1865, and then returned to Germany. By examining the proper motions of stars, he came up with his "Central Sun Hypothesis", according to which the center of the galaxy was located in the Pleiadesstar cluster and that the Sun revolves around it. He got the location wrong. He published many scientific works, among them a two-volume History of Descriptive Astronomy in 1873. In 1864, he proposed a calendar reform for Russia: After dropping 12 days to align with Gregorian calendar dates before the year 1900, the leap year in 1900 along with every 128th year afterwards under the Julian rules would be cancelled. This would give a mean year of 365 days, 5 hours, 48 minutes, 45 seconds, which is extremely close to the mean tropical year. Neither the Tsar nor Orthodox clergy accepted this unsolicited proposal, though a modified version of it was made by Sergey Glazenap in 1900, and ultimately Russia would adopt the Gregorian calendar in 1918. Notwithstanding several singular scientific errors, von Mädler, without doubt, is one of the great and eminent astronomers of the 19th century. The craters Mädler on the Moon and Mädler on Mars are both named in his honor.