His father, Afonso Sanches, was the firstborn and favorite son of King Dinis I of Portugal who had him out of wedlock with Aldonza Rodrigues Telha. Teresa Martins de Meneses, his mother, was the daughter of João Afonso Telo, the first count of Barcelos, and of Teresa Sánchez, an illegitimate daughter of Sancho IV the Brave, king of Castile and León. Teresa survived her husband by almost twenty years. João Afonso de Albuquerque was raised in Lisbon at the house of João Simão de Urrô who in 1314 gave him certain properties in the city and in Alenquer.
Already settled in Castile by around 1330 he appears often in charters confirming as the alférez of his cousin Alfonso XI and also as the tutor and later mayordomo of Infante Pedro, who was barely fifteen years old when his father died, forming a close relationship with the young king as his favorite and one of the most influential politicians in the kingdom. He was also the chancellor of King Alfonso XI and during part of the reign of his son Peter I. When the session of the Cortes de Valladolid of 1351 were convened, he was at the height of his power and had great influence on the decisions that were taken. Measures were passed to protect trade with Flanders, to organize the prosecution of wrongdoers, an attempt to normalize the precarious economic situation by controlling prices and wages, and to prepare a census of the Behetrías which resulted in the drafting of the Becerro de las Behetrías de Castilla, a detailed account of these communities and of their respective lords. He also played a key role in arranging the marriage of young King Peter I with Blanche, daughter of Peter I, Duke of Bourbon, with the aim bolstering the relationship between the kingdoms of Castile and France and was the best man at the wedding ceremony on 3 June 1353 at the Collegiate Church of Santa María la Mayor in Valladolid.
Albuquerque's policies, favorable to an alliance with France, together with his excessive influence in the affairs of the court, eventually distanced him from the king, who began to consider an approach to England. Fearing the royal ire, Albuquerque retired to his properties in Extremadura and then returned to Portugal. King Peter replaced the men who had been closest to Alburquerque with the kinsmen and friends of his mistress María de Padilla. It was during this time that he reached an agreement with the future King Henry II of Castile, who had formed a coalition with other noblemen to fight against his half-brother King Peter I. According to the Chronicle of Pero López de Ayala, "he met with Don Enrique and with the Grand Master of the Order of SantiagoFadrique, and the three of them reached an agreement", after which they went to Alburquerque, ravaged the lands of Badajoz and occupied Ciudad Rodrigo. A few days after the successful occupation of Medina del Campo by the rebels, João Afonso de Albuquerque died suddenly in that city in 1354, most probably poisoned, according to Pero López de Ayala, by a physician, following the orders of King Peter I, who gave him a poisonous potion.
Burial
After his death, the King's rivals carried his coffin throughout the kingdom and they did not bury him until King Peter I was defeated. His final resting place was the Monastery of Santa María de la Santa Espina in the province of Valladolid where his wife and their only son were subsequently buried.
Martin Gil de Alburquerque became lord of Alburquerque at the death of his father and was the adelantado of Murcia. He was executed by order of Peter the Cruel in 1365 and buried at the same monastery as his parents. His death marked the end of the principal line of this lineage and his estates were incorporated by Peter I in the crown.
João Afonso de Albuquerque had several children out of wedlock with Maria Rodrigues Barba, daughter of Rui Martins Barba and Iria Martins Alardo:
Maria Afonso de Albuquerque, the wife of Gonçalo Teles de Meneses, first Count of Neiva and Lord of Faria and brother of the husband of her sister Beatriz.
