In 2010, Pargo participated in the Orlando Pro Summer League for the Charlotte Bobcats, and then later in the Las VegasNBA Summer League, as a member of the Minnesota Timberwolves. On August 26, 2010, Pargo replaced Mikhail Torrance, who was suffering from a heart condition, signing a one-year contract with EuroLeague giants Maccabi Tel Aviv. After a promising start, he emerged as one of the team's main players, especially after Doron Perkins's season-ending injury. He helped Maccabi to reach the EuroLeague Final, earning an All-EuroLeague Second Team selection in the process. His team lost in the EuroLeague Finals to Panathinaikos, by a score of 78–70.
2011–12 season
On May 24, 2011, Pargo signed a new two-year contract extension with Maccabi. However, he broke the contract, and on December 10, 2011, he signed a two-year contract with the NBA's Memphis Grizzlies, with his successful EuroLeague season not having gone unnoticed.
2012–13 season
On July 25, 2012, he was traded to the Cleveland Cavaliers, along with a 2014 second round draft pick, in exchange for D. J. Kennedy. On January 22, 2013, Pargo was waived by the Cavaliers. On February 7, 2013, Pargo was signed to a ten-day contract by the Philadelphia 76ers. On February 18, 2013, Pargo was signed by the 76ers for the rest of the 2012–13 season. He was waived on April 1, 2013, when the team signed Justin Holiday.
2013–14 season
In June 2013, he signed a two-year contract worth $5.2 million net income with the Russian club CSKA Moscow.
2014–15 season
On July 24, 2014, Pargo and CSKA Moscow reached an agreement to part ways. Later that day, Pargo signed a two-year deal with his former club Maccabi Tel Aviv.
2015–16 season
On July 4, 2015, he parted ways with Maccabi, signing with the Chinese club Zhejiang Lions for the 2015–16 CBA season. On April 27, 2016, Pargo joined the Italian club Reyer Venezia, for the remainder of the 2015–16 season.
On July 11, 2018, Pargo signed a one-year contract extension with Maccabi Tel Aviv. Pargo won the 2019 Israeli League Championship with Maccabi, winning the Israeli League title for two consecutive years.
2019–20 season
On November 7, 2019, Pargo joined the Santa Cruz Warriors of the NBA G League for a second stint. He scored 37 points against the South Bay Lakers on December 10. On February 8, 2020, Pargo signed a 10-day contract with the Golden State Warriors. In his debut the same day against the Lakers, Pargo appeared in an NBA game for the first time in six years, 316 days — the sixth-longest gap between game appearances in NBA history. Pargo posted 15 points in a 112-106 loss to the Phoenix Suns.
2020–21 season
On June 3, 2020, Pargo signed with Hapoel Jerusalem.
In the summer of 2017, Pargo played in The Basketball Tournament —a single-elimination winner-take-all tournament—for team Few Good Men. He averaged 13.3 points per game and helped take the team to the Super 16 round of TBT 2017, where they lost to Team Challenge ALS, 77–60. In TBT 2018, Pargo played for Overseas Elite, the three-time defending champion. In six games, he averaged 7.7 PPG, 3.3 assists per game and 2.3 rebounds per game. Overseas Elite reached the championship game and defeated Eberlein Drive, 70–58, for their fourth consecutive TBT title. In TBT 2019, Pargo and Overseas Elite advanced to the semifinals where they suffered their first-ever defeat, losing to Carmen's Crew, 71–66.
