Grillo began her career as an assistant literary manager at Circle Repertory Company, under co-founder Marshall Mason, where she was a member of the emerging writer/director/actor Lab. She then worked at New Line Cinema in the New York office for 10 years, rising through the ranks from freelance script reader, becoming the studio's first Story Editor and first Director of Acquisitions, establishing both departments, to eventually become the Sr. VP of Production/East Coast, under the President of Productions, Sara Risher and President/Founder Bob Shaye. During her tenure at New Line, she launched the House Party franchise and the careers of filmmakers Reggie Hudlin, Ted Demme, and David O. Russell, whom Grillo married in 1992. She also executive producedSundance Film Festival award-winning films Spanking the Monkey and Hangin' with the Homeboys. As an independent producer, Grillo executive produced Joe the King, and produced Searching for Paradise, which was developed at the Sundance Labs and aired on the Sundance Channel. She received an Emmy Award as executive producer of HBO's documentary .
''Fly Away''
In 2011, Grillo wrote, directed and produced the ultra-low-budget feature Fly Away starring Ashley Rickards of MTV's Awkward . The film premiered in dramatic competition at SXSW in 2011, won Jury Prize for Best Performance at Arizona International Film Festival and was nominated for a Voice Award for its depiction of mental illness. Fly Away opened in limited release to critical acclaim from The New York Times, Los Angeles Times, HuffPost, New York Observer, Variety, and The Hollywood Reporter. Critic Rex Reed of the New York Observer said it deserved an Academy Award nomination, and Los Angeles Times Calendar Section sited it as one of the four indie film performances most overlooked for Oscar nomination that year.
''Jack of The Red Hearts''
Most recently, Grillo directed and executive produced Jack of the Red Hearts, a narrative feature starring Famke Janssen and AnnaSophia Robb. It won the Jury Prize at the inaugural Bentonville Film Festival, which was co-founded by actress/activist Geena Davis to advance women and diversity. The film also won the Audience Award for the Best Narrative Feature, the Jury Award for the Best Feature Narrative and the Director Prize for Best Young Actress at Woods Hole Film Festival 2015, and The Chimaera Project Award at the Catalina Film Festival 2015.
Personal life
She has one son, Matthew Russell, with ex-husband David O. Russell.