Entering his freshman season for The Ensworth School in Nashville, Tennessee, Wiseman stood and weighed 200 pounds. He was teammates with future NBA player Jordan Bone. By June 2016, ESPN ranked Wiseman among its top 25 players in the 2019 recruiting class. In 2016, he played for the St. Louis Eagles Amateur Athletic Union team. As a sophomore in 2016–17, he guided Ensworth to the Tennessee Secondary School Athletic Association Division II-AA semifinals. He averaged about 20 points and six rebounds per game and was named MaxPreps Sophomore All-American honorable mention. In May 2017, Wiseman joined Team Penny, founded by former National Basketball Association player Penny Hardaway, on the Nike Elite Youth Basketball League circuit. In August, he announced his transfer to Memphis East High School in Memphis, Tennessee, where Hardaway was promoted to head coach. On November 16, 2017, the TSSAA ruled Wiseman ineligible for his junior season because an "athletic coaching link" existed between him and Hardaway. However, on December 13, he was cleared to play because the TSSAA rule was "not clear in its application." During the season, Wiseman rose to become the number one overall recruit by ESPN in the 2019 class. On March 17, 2018, he led Memphis East to a TSSAA Class AAA championship, leading all scorers with 19 points. He averaged 18.5 points, 8.2 rebounds, and 2.8 blocks per game, earning MaxPreps Junior All-American third team recognition. Entering his senior season, Wiseman remained at Memphis East instead of transferring to a prep school, citing "the East High tradition" and the improvements he made as a junior with the program. On March 1, 2019, he recorded a triple-double of 27 points, 20 rebounds, and 10 blocks to help his team win the Region 8AAA championship. Memphis East finished as TSSAA Class AAA runners-up to Bearden High School, even though Wiseman posted 24 points, 11 rebounds, and five blocks in his final high school game. After averaging 25.8 points, 14.8 rebounds, and 5.5 blocks as a senior, he was named Gatorade National Player of the Year and Morgan Wootten National Player of the Year. Wiseman also won the Tennessee Class AAA Mr. Basketball award while appearing in the McDonald's All-American Game, the Jordan Brand Classic, and the Nike Hoop Summit. He shared most valuable player accolades with Cole Anthony at the Jordan Brand Classic. In October 2019, after Wiseman had moved on to the University of Memphis, the TSSAA's original ruling of ineligibility for the 2017–18 season was upheld by a Memphis judge, who ruled that the TSSAA coaching link rule was not too vague and did not violate Wiseman's property rights as an athlete.
Recruiting
Wiseman was a consensus five-star recruit out of high school and was considered the top recruit in the 2019 class by 247Sports and ESPN. On November 20, 2018, he committed to Memphis despite strongly considering Kentucky. As a result, he reunited with former high school coach Penny Hardaway, who had become the team's head coach in the previous season. On November 29, Wiseman signed a National Letter of Intent to play college basketball for Memphis.
College career
In August 2019, a minor shoulder injury kept Wiseman from joining Memphis for a series of preseason exhibition games in Nassau, Bahamas. He missed his team's two preseason games in October after sustaining an ankle injury. On November 5, Wiseman made his regular season debut with 28 points, 11 rebounds, and three blocks in 22 minutes as the Tigers defeated South Carolina State, 97–64. On November 8, Wiseman's lawyers announced that the National Collegiate Athletic Association ruled him ineligible to play for Memphis. The University of Memphis stated that head coach Penny Hardaway had paid for $11,500 in moving expenses to help him and his family move to the city of Memphis in 2017. According to Wiseman's lawyer, Leslie Ballin, the NCAA deemed that Hardaway, a Memphis alumnus, had acted as a booster. On the same day, a Shelby County judge granted Wiseman a temporary restraining order against the NCAA's ruling, allowing him to keep playing. Less than two hours later, he had 17 points and nine rebounds to lead Memphis past UIC, 92–46. Wiseman's lawyers filed a lawsuit against the NCAA to restore his eligibility before withdrawing the case six days later in hopes of reaching an agreement. On November 20, the NCAA ruled that Wiseman would be eligible to return on January 12 after serving a 12-game suspension if he donated $11,500 to a charity of his choice. On December 19, 2019, after missing seven games due to suspension, Wiseman announced that he would leave Memphis, hire an agent and prepare for the 2020 NBA draft, effectively ending his college career. He was one of the highest rated prospects in his class, according to draft analysts.